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Titolo:
INTRAVENOUS IMMUNOGLOBULIN TREATMENT IN THERAPY-RESISTANT EPIDERMOLYSIS-BULLOSA ACQUISITA
Autore:
KOFLER H; WAMBACHERGASSER B; TOPAR G; WEINLICH G; SCHULER C; HINTNER H; ROMANI N; FRITSCH P;
Indirizzi:
INNSBRUCK UNIV,DERMATOL & VENEREOL KLIN,DEPT DERMATOL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA GEN HOSP SALZBURG,DEPT DERMATOL SALZBURG AUSTRIA
Titolo Testata:
Journal of the American Academy of Dermatology
fascicolo: 2, volume: 36, anno: 1997,
parte:, 2
pagine: 331 - 335
SICI:
0190-9622(1997)36:2<331:IITITE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE GLOBULIN; CYCLOSPORINE-A; VII COLLAGEN; EFFICACY; IMMUNOFLUORESCENCE; INFUSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Kofler et al., "INTRAVENOUS IMMUNOGLOBULIN TREATMENT IN THERAPY-RESISTANT EPIDERMOLYSIS-BULLOSA ACQUISITA", Journal of the American Academy of Dermatology, 36(2), 1997, pp. 331-335

Abstract

Epidermolysis bullosa acquisita is an uncommon autoimmune bullous disease of the skin and mucous membranes. It is chronic, disabling, and difficult to treat. We describe a case of severe epidermolysis bullosa acquisita of 7 years' duration that had been treated with azathioprine, corticosteroids, chlorambucil, plasma exchanges, cyclophosphamide, cyclosporine, and colchicine without any lasting effect. Seven cycles of treatment were administered with immunoglobulin given intravenously at a low dose, 40 mg/kg body weight daily for 5 days. The patient was free of disease for 10 months after the initiation of therapy. We suggest that low-dose regimens of immunoglobulins may be as effective in this disease as the high-dose regimens suggested in the literature, andat much lower cost.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:35:12