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Titolo:
CUTANEOUS INVOLVEMENT IN PRELYMPHOMATOUS ANGIOIMMUNOBLASTIC LYMPHADENOPATHY
Autore:
SCHMUTH M; RAMAKER J; TRAUTMANN C; HUMMEL M; SCHMITTGRAFF A; STEIN H; GOERDT S;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,HAUTKLIN & POLIKLIN,HINDENBURGDAMM 30 D-12200 BERLIN GERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,HAUTKLIN & POLIKLIN D-12200 BERLIN GERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,INST PATHOL D-12200 BERLIN GERMANY
Titolo Testata:
Journal of the American Academy of Dermatology
fascicolo: 2, volume: 36, anno: 1997,
parte:, 2
pagine: 290 - 295
SICI:
0190-9622(1997)36:2<290:CIIPAL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; IMMUNOBLASTIC LYMPHADENOPATHY; DYSPROTEINEMIA; DISEASE; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Schmuth et al., "CUTANEOUS INVOLVEMENT IN PRELYMPHOMATOUS ANGIOIMMUNOBLASTIC LYMPHADENOPATHY", Journal of the American Academy of Dermatology, 36(2), 1997, pp. 290-295

Abstract

We describe prelymphomatous angioimmunoblastic lymphadenopathy with cutaneous involvement in a 73-year-old female patient. A maculopapular skin eruption was the first sign of the disease. Skin histology showedextensive perivascular and periadnexal mixed lymphoid infiltrates including centroblasts and immunoblasts with a high proliferative index and with focal erythrocyte extravasation. Lymph node histology confirmed the diagnosis, showing nearly complete effacement of the follicular architecture, a mixed lymphoid infiltrate, and numerous high endothelial venules in an expanded T-cell zone. Immunohistochemistry, however, demonstrated preservation of at least some follicular structures. T-cell receptor gene rearrangement analysis revealed oligoclonal patterns in both lymph node and skin specimens. In contrast, immunoglobulin heavy-chain gene rearrangement analysis revealed a polyclonal pattern. Accordingly, the disease was classified as a prelymphomatous stage of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) with specific involvement of both lymph node and skin. The patient was treated with high-dose corticosteroids, and long-lasting remission was induced. In contrast to our case, most reported cases of AILD show a monoclonal T-cell pattern indicating AILD-type lymphoma. Therefore we discuss the concept of prelymphomatous AILD developing into AILD-type lymphoma. Persistence of some antigenic stimulus may induce the proliferation of a monoclonal population of lymphoid cells from a polyclonal background in a multistep fashion. Proper treatment of AILD at an early, prelymphomatous stage may protract or inhibit development of full-blown, fatal AILD-type lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:32:38