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Titolo:
SUPRATENTORIAL GLIOMAS - A COMPARATIVE-STUDY BY GRADE AND HISTOLOGIC TYPE
Autore:
SHAW EG; SCHEITHAUER BW; OFALLON JR;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV RADIAT ONCOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CANC STAT UNIT ROCHESTER MN 55905
Titolo Testata:
Journal of neuro-oncology
fascicolo: 3, volume: 31, anno: 1997,
pagine: 273 - 278
SICI:
0167-594X(1997)31:3<273:SG-ACB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; ASTROCYTOMAS; OLIGODENDROGLIOMA; SURVIVAL; ADULTS;
Keywords:
PILOCYTIC ASTROCYTOMA; DIFFUSE FIBRILLARY ASTROCYTOMA; OLIGODENDROGLIOMA; MIXED OLIGO-ASTROCYTOMA; GRADING SYSTEM; OUTCOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Shaw et al., "SUPRATENTORIAL GLIOMAS - A COMPARATIVE-STUDY BY GRADE AND HISTOLOGIC TYPE", Journal of neuro-oncology, 31(3), 1997, pp. 273-278

Abstract

Purpose: To try and identify biologic differences based on tumor grade and histologic type between the major classes of glial tumors, including low-grade diffuse fibrillary and pilocytic astrocytomas, oligodendrogliomas, and mixed oligo-astrocytomas, and high-grade diffuse fibrillary astrocytomas, oligodendrogliomas, and mixed oligo-astrocytomas. Methods: Utilizing the St. Anne-Mayo (SAM) grading system, the incidence, patient characteristics, and survivals of 196 patients with low-grade (SAM grade 1 + 2) and 318 patients with high-grade (SAM 3 + 4) supratentorial tumors were compared. Results: Among low-grade tumors, most favorable were 5- and 10-year survival rates for patients with pilocytic astrocytomas, which were 85% and 79%, respectively. Median survival and 5- and 10-year survival rates for the other low-grade tumors were lower, and were proportionately improved by the presence of an oligodendroglial component: diffuse fibrillary astrocytomas - 4.7 years, 46 %, and 17%, oligodendroglioma 9.8 years, 73%, and 49%; and mixed oligo-astrocytoma - 7.1 years, 63%, and 33%, respectively. For high-gradetumors, patients with either oligodendrogliomas or mixed oligo-astrocytomas had comparable favorable survivals in comparison to diffuse fibrillary astrocytomas. Median survivals and 5- and 10-year survival rates were 4.5 years, 45%, and 15% for the oligodendrogliomas and mixed oligo-astrocytomas versus 0.8 years, 3%, and 0% for the diffuse fibrillary astrocytomas, respectively. Conclusion: These survival data suggest that both low-grade and high-grade supratentorial gliomas have outcomes which are highly dependent upon histologic type.

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Documento generato il 27/11/20 alle ore 15:12:24