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Titolo:
PERFUSION IMAGING OF THE RAT-KIDNEY WITH MR
Autore:
WILLIAMS DS; ZHANG WG; KORETSKY AP; ADLER S;
Indirizzi:
CARNEGIE MELLON UNIV,PITTSBURGH NMR CTR BIOMED RES,4400 5TH AVE PITTSBURGH PA 15213 CARNEGIE MELLON UNIV,DEPT BIOL SCI PITTSBURGH PA 15213 UNIV PITTSBURGH,SCH MED,DEPT MED PITTSBURGH PA 00000
Titolo Testata:
Radiology
fascicolo: 3, volume: 190, anno: 1994,
pagine: 813 - 818
SICI:
0033-8419(1994)190:3<813:PIOTRW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; ARTERIAL WATER; RELAXATION; INVERSION;
Keywords:
BLOOD, FLOW DYNAMICS; KIDNEY, PERFUSION, 81.12144; MAGNETIC RESONANCE (MR), PERFUSION STUDY, 961.12944; RENAL ARTERIES, FLOW DYNAMICS, 961.12944; RENAL ARTERIES, MR, 961.12944;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Williams et al., "PERFUSION IMAGING OF THE RAT-KIDNEY WITH MR", Radiology, 190(3), 1994, pp. 813-818

Abstract

PURPOSE To develop a technique for measurement of regional renal perfusion with magnetic resonance (MR) imaging. MATERIALS AND METHODS: Quantitative renal perfusion images in rats were obtained by measurement of the reduction in kidney MR image signal intensity after steady state magnetic labeling of arterial blood in the suprarenal aorta. Labeling was achieved with adiabatic fast passage inversion of arterial water. RESULTS: Cortical renal blood flow was 4.9 mL/g/min +/- 0.15 (12 rats), which correlated well with previous measurements obtained with other techniques. Serial perfusion images obtained every 5 minutes duringintravenous infusion of either acetylcholine or angiotensin II showedthat one increased and the other decreased renal blood flow, respectively, also correlating with previous measurements. CONCLUSION: Quantitative measurement of cortical renal blood flow can be obtained with proton MR imaging techniques, with use of endogenous arterial water as atracer. This technique should be readily applicable to measurement ofrenal perfusion in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:57:58