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Titolo:
COMPARISON OF INTRACRANIAL INFUSIONS OF COLCHICINE AND IBOTENIC ACID AS MODELS OF NEURODEGENERATION IN THE BASAL FOREBRAIN
Autore:
SHAUGHNESSY LW; BARONE S; MUNDY WR; HERR DW; TILSON HA;
Indirizzi:
US EPA,DIV NEUROTOXICOL,MD74B RES TRIANGLE PK NC 27711 US EPA,DIV NEUROTOXICOL RES TRIANGLE PK NC 27711 UNIV N CAROLINA,CURRICULUM NEUROBIOL CHAPEL HILL NC 27599 MANTECH ENVIRONM TECHNOL INC RES TRIANGLE PK NC 27709
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 637, anno: 1994,
pagine: 15 - 26
SICI:
0006-8993(1994)637:1-2<15:COIIOC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS; CHOLINERGIC NEURONS; ALZHEIMERS-DISEASE; NEUROTOXIC LESIONS; SENILE DEMENTIA; QUISQUALIC ACID; DENTATE GYRUS; CELL-DEATH; WATER-MAZE; RAT;
Keywords:
COLCHICINE; IBOTENIC ACID; NUCLEUS BASALIS; CHOLINERGIC HYPOFUNCTION; GLUTAMIC ACID DECARBOXYLASE; BIOGENIC AMINE; PASSIVE AVOIDANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
L.W. Shaughnessy et al., "COMPARISON OF INTRACRANIAL INFUSIONS OF COLCHICINE AND IBOTENIC ACID AS MODELS OF NEURODEGENERATION IN THE BASAL FOREBRAIN", Brain research, 637(1-2), 1994, pp. 15-26

Abstract

Colchicine and ibotenic acid were compared for their ability to produce neurodegeneration and cognitive deficit after bilateral infusions into the nucleus basalis magnocellularis of male Long-Evans rats. Four weeks post-lesion, there was no difference in locomotor activity following infusion of either neurotoxicant or vehicle. In a passive avoidance task, both treated groups had significantly shorter step-through latencies compared with vehicle. Five weeks post-lesion, rats were killed for neurochemistry or histochemistry. Choline acetyltransferase (ChAT) activity in both the frontal and parietal cortex was significantly decreased (25-35%) in the colchicine- and ibotenic acid-infused rats when compared to control. There was no effect of either neurotoxicant on ChAT activity in the hippocampus or striatum. Both neurotoxicants produced damage in the general area of the ventromedial pallidum, although ibotenic acid infusion consistently produced a larger area of damage as assessed in Nissl-stained sections. Analysis of the number of ChAT-immunoreactive cells in the nucleus basalis magnocellularis (NBM) showed an average 60% cell loss following colchicine infusion and a 75% cell loss after ibotenic acid infusion. Area of glutamic acid decarboxylase (GAD) staining was significantly decreased in several regions surrounding the NBM for ibotenic acid (51% average decrease), and showednon-significant decreases (28%) following colchicine infusion. Colchicine infusion decreased dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum; ibotenic acid had no effect on brain catechol or indoleamine levels. The results indicate that although similar cholinergic hypofunction and behavioral deficits were achieved, several non-cholinergic differences between the neurotoxicants were detected.

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Documento generato il 29/03/20 alle ore 14:40:38