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Titolo:
DOPAMINERGIC FUNCTION IN FAMILIAL PARKINSONS-DISEASE - A CLINICAL ANDF-18 DOPA POSITRON EMISSION TOMOGRAPHY STUDY
Autore:
PICCINI P; MORRISH PK; TURJANSKI N; SAWLE GV; BURN DJ; WEEKS RA; MARK MH; MARAGANORE DM; LEES AJ; BROOKS DJ;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,DU CANE RD LONDON W12 0NN ENGLAND UNIV MED & DENT NEW JERSEY NEW BRUNSWICK NJ 00000 MAYO CLIN,DEPT NEUROL ROCHESTER MN 00000 NATL HOSP NEUROL LONDON ENGLAND
Titolo Testata:
Annals of neurology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 222 - 229
SICI:
0364-5134(1997)41:2<222:DFIFP->2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE SYSTEM ATROPHY; F-18 DOPA UPTAKE; AUTOSOMAL-DOMINANT; LEWY-BODY; ANTICIPATION; ONSET; TWINS; BRAIN; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
P. Piccini et al., "DOPAMINERGIC FUNCTION IN FAMILIAL PARKINSONS-DISEASE - A CLINICAL ANDF-18 DOPA POSITRON EMISSION TOMOGRAPHY STUDY", Annals of neurology, 41(2), 1997, pp. 222-229

Abstract

There is increasing evidence for familial aggregation in Parkinson's disease (PD). It is possible that some asymptomatic relatives of PD patients have subclinical nigral Lewy body pathology and their identification could help determine the true prevalence of the disease. We usedF-18-dopa positron emission tomography to investigate nigrostriatal dopaminergic terminal function in asymptomatic members of 7 unrelated kindreds in which at lease 2 members had parkinsonism. Eight (25%) of the 32 asymptomatic relatives showed abnormal putamen F-18-dopa uptake (2.5 standard deviations below the normal mean). When discriminant function analysis was applied, all of these 8 subjects plus another 3 were classified with high probability as having PD. On neurological examination, 5 of the 32 relatives scanned had an isolated mild postural tremor and 2 of these 5 had reduced putamen uptake. Our findings providefurther support for a role of inheritance in the etiology of PD and suggest that the penetrance for nigrostriatal dopaminergic dysfunction in familial clusters of PD is higher than the prevalence of clinical parkinsonism reported in epidemiological surveys.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:34:51