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Titolo:
-DIMETHYL-1,2,3,4-TETRAHYDRO-6H-QUININDOLIN-1-ONE, A NOVEL GABA(A) MODULATOR WITH POTENTIAL ANXIOLYTIC ACTIVITY
Autore:
BLACKBURN TP; BOLTON D; FORBES IT; JOHNSON CN; MARTIN RT; THOMAS DR; THOMPSON M; UPTON N;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,COLDHARBOUR RD HARLOW CM19 5AD ESSEX ENGLAND SMITHKLINE BEECHAM PHARMACEUT HARLOW CM19 5AD ESSEX ENGLAND
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 2, volume: 4, anno: 1994,
pagine: 279 - 284
SICI:
0960-894X(1994)4:2<279:-ANGM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING; CHLORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Blackburn et al., "-DIMETHYL-1,2,3,4-TETRAHYDRO-6H-QUININDOLIN-1-ONE, A NOVEL GABA(A) MODULATOR WITH POTENTIAL ANXIOLYTIC ACTIVITY", Bioorganic & medicinal chemistry letters, 4(2), 1994, pp. 279-284

Abstract

Ketone isosteres have been investigated in a series of pyrido[2,3-b]indoles (alpha-carbolines). The incorporation of ring fusion into alpha-carbolines to produce the rigid quinindoline nucleus provides a GABA(A) modulator with both increased potency and a longer duration of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 09:26:16