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Titolo:
HYPONATREMIA ASSOCIATED WITH CARBAMAZEPINE AND OXCARBAZEPINE THERAPY - A REVIEW
Autore:
VANAMELSVOORT T; BAKSHI R; DEVAUX CB; SCHWABE S;
Indirizzi:
CIBA LTD,DEPT MED & CLIN DEV,K-147412 CH-4002 BASEL SWITZERLAND CIBA LTD,DEPT MED & CLIN DEV CH-4002 BASEL SWITZERLAND
Titolo Testata:
Epilepsia
fascicolo: 1, volume: 35, anno: 1994,
pagine: 181 - 188
SICI:
0013-9580(1994)35:1<181:HAWCAO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE VASOPRESSIN CONCENTRATIONS; INDUCED WATER-INTOXICATION; ANTIDIURETIC-HORMONE; SERUM SODIUM; DILUTIONAL HYPONATREMIA; PLASMA; SECRETION; CHILDREN; ELECTROLYTES; MANAGEMENT;
Keywords:
ANTICONVULSANTS; TOXIC EFFECTS; CARBAMAZEPINE; OXCARBAZEPINE; EPILEPSY; AFFECTIVE DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
T. Vanamelsvoort et al., "HYPONATREMIA ASSOCIATED WITH CARBAMAZEPINE AND OXCARBAZEPINE THERAPY - A REVIEW", Epilepsia, 35(1), 1994, pp. 181-188

Abstract

Hyponatremia, an electrolyte disturbance usually without clinical significance, may sometimes lead to serious complications when overlookedor not treated appropriately. One cause of hyponatremia, the syndromeof inappropriate antidiuretic hormone (SIADH) secretion, has been associated with some drugs, including car bamazepine (CBZ). Because of its antidiuretic effects, CBZ has been used successfully to treat diabetes insipidus centralis. Possible mechanisms for the antidiuretic effects of CBZ have been proposed. Altered sensitivity to serum osmolality by the hypothalamic osmoreceptors appears likely, but an increased sensitivity of the renal tubules to circulating ADH cannot be excluded. CBZ has led to hyponatremia in patients with epilepsy, neuralgia, mental retardation, and psychiatric disorders with a frequency varying from4.8 to 40%. Oxcarbazepine (OCBZ), which is structurally related to CBZ, has shown similar hyponatremic effects, but whether hyponatremia occurs more often than with CBZ is not yet clear. Experience with OCBZ is still limited, and there is no definite explanation for a possible difference in antidiuretic potency. Most patients with CBZ/OCBZ-inducedhyponatremia are asymptomatic. In rare cases, water intoxication has been reported, necessitating treatment discontinuation.

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Documento generato il 03/07/20 alle ore 01:26:20