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Titolo:
COMPARISONS OF ATP TURNOVER IN HUMAN MUSCLE DURING ISCHEMIC AND AEROBIC EXERCISE USING P-31 MAGNETIC-RESONANCE SPECTROSCOPY
Autore:
KEMP GJ; THOMPSON CH; BARNES PRJ; RADDA GK;
Indirizzi:
JOHN RADCLIFFE HOSP,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT OXFORD OX3 9DU ENGLAND UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN NEUROL OXFORD OX2 6HE ENGLAND
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 3, volume: 31, anno: 1994,
pagine: 248 - 258
SICI:
0740-3194(1994)31:3<248:COATIH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; OXYGEN-CONSUMPTION; WORK TRANSITIONS; HEART-FAILURE; METABOLISM; INVIVO; CAPACITY; RESPIRATION; MODEL; COST;
Keywords:
ATP TURNOVER; BIOENERGETICS; P-31 MAGNETIC RESONANCE SPECTROSCOPY; SKELETAL MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Kemp et al., "COMPARISONS OF ATP TURNOVER IN HUMAN MUSCLE DURING ISCHEMIC AND AEROBIC EXERCISE USING P-31 MAGNETIC-RESONANCE SPECTROSCOPY", Magnetic resonance in medicine, 31(3), 1994, pp. 248-258

Abstract

To investigate human muscle bioenergetics quantitatively in vivo, we used P-31 magnetic resonance spectroscopy to study the flexor digitorum superficialis of four adult males during dynamic ischemic and aerobic exercise at 0.50-1.00 W and during recovery from aerobic exercise. During exercise, changes in pH and [PCr] were larger at higher power, but in aerobic exercise neither end-exercise [ADP] nor the initial postexercise PCr resynthesis rate altered with power. In ischemic exercisewe estimated total ATP synthesis from the rates of PCr depletion and glycogenolysis (inferred using an analysis of proton buffering); this was linear with power output. In aerobic exercise, again we estimated ATP synthesis rates due to phosphocreatine hydrolysis and glycogenolysis (incorporating a correction for proton efflux) and also estimated oxidative ATP synthesis by difference, using the total ATP turnover rate established during ischemic exercise. We conclude that in early exercise oxidative ATP synthesis was small, increasing by the end of exercise to a value close (as predicted) to the initial postexercise rate of PCr resynthesis. Furthermore, a plausible estimate of proton efflux during aerobic exercise can be inferred from the pH-dependence of proton efflux in recovery.

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Documento generato il 26/09/20 alle ore 22:40:02