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Titolo:
ALTERATION OF THE THYMUS IN MYASTHENIA-GR AVIS AND ITS PATHOGENETIC RELEVANCE
Autore:
KIRCHNER T; MARX A;
Indirizzi:
UNIV ERLANGEN NURNBERG,INST PATHOL,KRANKENHAUSSTR 8-10 D-91054 ERLANGEN GERMANY UNIV WURZBURG,INST PATHOL W-8700 WURZBURG GERMANY
Titolo Testata:
Nervenheilkunde
fascicolo: 1, volume: 13, anno: 1994,
pagine: 3 - 7
SICI:
0722-1541(1994)13:1<3:AOTTIM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
GER
Soggetto:
NICOTINIC ACETYLCHOLINE-RECEPTOR; CELL-LINE TE671; ALPHA-SUBUNIT; MONOCLONAL-ANTIBODIES; GAMMA-SUBUNIT; MUSCLE; DETERMINANTS; EPITOPES; THYMOMAS; CDNA;
Keywords:
THYMUS; MYASTHENIA GRAVIS; AUTOIMMUNE DISEASE; PATHOLOGY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
T. Kirchner e A. Marx, "ALTERATION OF THE THYMUS IN MYASTHENIA-GR AVIS AND ITS PATHOGENETIC RELEVANCE", Nervenheilkunde, 13(1), 1994, pp. 3-7

Abstract

The thymic alterations in myasthenia gravis (MG) are heterogeneous. They comprise thymitis or thymoma as frequent findings, thymolipoma andtrue thymic hyperplasia as rare diagnosis, and even a normal thymus in 11,3% of the cases. These different pathologic features of the thymus might reflect various ways of pathogenesis in MG with the common link of an intrathymic or intratumorous presence of AChR-epitopes. Thus the expression of fetal AChRs on myoid cells and of a distinct AChR-epitope on epithelial cells of the thymic medulla seems to be the prerequisite of autoimmune-thymitis in patients with certain HLA-haplotypes. On the other hand the aberrant hyperexpression of a p153 protein sharing an epitope with the AChR might cause a false-positive selection of AChR-specific autoreactive T-cells in thymomas, which eventually initiate paraneoplastic MG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:44:10