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Titolo:
ASSOCIATION OF DOPAMINE D2 RECEPTOR MOLECULAR VARIANT WITH SCHIZOPHRENIA
Autore:
ARINAMI T; ITOKAWA M; ENGUCHI H; TAGAYA H; YANO S; SHIMIZU H; HAMAGUCHI H; TORU M;
Indirizzi:
UNIV TSUKUBA,INST BASIC MED SCI,DEPT MED GENET TSUKUBA IBARAKI 305 JAPAN TOKYO MED & DENT UNIV,DEPT NEUROPSYCHIAT TOKYO TOKYO JAPAN HOKUSHIN GEN HOSP,DEPT PSYCHIAT NAKANO NAGANO JAPAN
Titolo Testata:
Lancet
fascicolo: 8899, volume: 343, anno: 1994,
pagine: 703 - 704
SICI:
0140-6736(1994)343:8899<703:AODDRM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
T. Arinami et al., "ASSOCIATION OF DOPAMINE D2 RECEPTOR MOLECULAR VARIANT WITH SCHIZOPHRENIA", Lancet, 343(8899), 1994, pp. 703-704

Abstract

We have examined a variant of the dopamine D2 receptor gene (Ser311-->Cys) in 156 Japanese schizophrenic patients and 300 controls. The allele frequency of Cys311 was significantly higher in the whole patient group (0.054), among patients with onset before age 25 (0.090), and among those with a family history (0.135) than in the controls (0.018). 3 patients were homozygous for Cys311. The patients with Cys311 showedsignificantly less severe thought disorder and negative symptoms of schizophrenia than those without Cys311. The Cys311 variant of the D2 receptor may be a genetic risk factor for some types of schizophrenia.

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Documento generato il 16/07/20 alle ore 18:36:57