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Titolo:
EXPRESSION OF BETA-1-6-BRANCHED N-LINKED OLIGOSACCHARIDES IS ASSOCIATED WITH ACTIVATION IN HUMAN T4 AND T8 CELL-POPULATIONS
Autore:
LEMAIRE S; DERAPPE C; MICHALSKI JC; AUBERY M; NEEL D;
Indirizzi:
UNIV PARIS 05,INSERM,U180,45 RUE ST PERES F-75006 PARIS FRANCE UNIV PARIS 05,INSERM,U180 F-75006 PARIS FRANCE UNIV SCI & TECHNOL LILLE 1,CNRS,UMR 111,CHIM BIOL LAB F-59655 VILLENEUVE DASCQ FRANCE
Titolo Testata:
The Journal of biological chemistry
fascicolo: 11, volume: 269, anno: 1994,
pagine: 8069 - 8074
SICI:
0021-9258(1994)269:11<8069:EOBNOI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAS-LIQUID-CHROMATOGRAPHY; METASTATIC TUMOR-CELLS; MEMBRANE-GLYCOPROTEINS; METHYL GLYCOSIDES; GLYCOSYLATION; LINES; DIFFERENTIATION; PROTEINS; BINDING; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S. Lemaire et al., "EXPRESSION OF BETA-1-6-BRANCHED N-LINKED OLIGOSACCHARIDES IS ASSOCIATED WITH ACTIVATION IN HUMAN T4 AND T8 CELL-POPULATIONS", The Journal of biological chemistry, 269(11), 1994, pp. 8069-8074

Abstract

Activation of human T lymphocytes by phorbol 12-myristate 13-acetate and leukoagglutinin from Phaseolus vulgaris (L PHA) results in important changes in N-glycosylation. The most important event is the increase, in both T4 and T8 cells (especially the latter), of L-PHA(+) structures characterized by beta 1-6-branching of complex-type oligosaccharides. Moreover, the existence of a CD4-mediated increase of these beta 1-6-branched structures on positively selected T4 cells, as compared with the negatively selected ones, suggests that the presence of these structures, not detectable on T8 resting cells, could be related to stimulation events triggered by both selection methods. This beta 1-6-branching on N-glycans, strongly associated with a metastatic phenotype in human and rodent tumors, is exhibited by numerous glycoproteins on stimulated cells, as shown by blot analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:58:54