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Titolo:
3-DIMENSIONAL PERFORMANCE OF A SMALL-DIAMETER POSITRON EMISSION TOMOGRAPH
Autore:
BLOOMFIELD PM; MYERS R; HUME SP; SPINKS TJ; LAMMERTSMA AA; JONES T;
Indirizzi:
HAMMERSMITH HOSP,PET,METHODOL GRP,CYCLOTRON UNIT,MRC,CLIN SCI CTR,DUCANE RD LONDON W12 0NN ENGLAND
Titolo Testata:
Physics in medicine and biology
fascicolo: 2, volume: 42, anno: 1997,
pagine: 389 - 400
SICI:
0031-9155(1997)42:2<389:3POASP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Bloomfield et al., "3-DIMENSIONAL PERFORMANCE OF A SMALL-DIAMETER POSITRON EMISSION TOMOGRAPH", Physics in medicine and biology, 42(2), 1997, pp. 389-400

Abstract

Recently, the initial 2D physical characterization of a small-diameter positron emission tomograph, designed specifically for scanning of small laboratory animals, was reported. The physical characteristics ofthe tomograph operating in 3D mode have now been measured and compared to those obtained in 2D mode. In 3D, the transaxial resolution was measured as 2.4+/-0.1 mm full width at half maximum (FWHM) and 6.7+/-1.1 mm full width at tenth maximum (FWTM) at the centre of the transaxial field of view (FOV). These values degraded to 4.5+/-0.3 mm (tangential) and 6.6+/-0.3 mm (radial) FWHM and 10.6+/-1.6 mm (tangential) and 11.2+/-2.1 mm (radial) FWTM, respectively, at a radial distance of 40 mm from the centre of the transaxial FOV. The axial resolution was measured as 4.6+/-0.1 mm FWHM and 15.0+/-0.5 mm FWTM at the centre of thetransaxial FOV, increasing to 5.0+/-0.1 mm FWHM and 18.8+/-3.7 mm FWTM at a radial distance of 40 mm from the centre of the transaxial FOV. These resolutions are similar to those obtained for the tomograph operating in 2D mode. The sensitivity of the tomograph operating in 3D was 4.31x10(4) counts s(-1) MBq(-1) at 250-850 keV compared to 0.995x10(4) counts s(-1) MBq(-1) in 2D at the same energy thresholds. In this energy window the noise equivalent count rate peaked at 4.1x10(4) counts s(-1), compared to 1.03x10(4) counts s(-1) in 2D. A scatter fractionof 30.2% at 250-850 keV was measured for a F-18 line source centred in a 60 mm diameter water filled phantom in 3D, compared to 31.0% in 2Dfor the same scanning geometry and energy thresholds. A comparison was made between 2D and 3D kinetic analyses for a group of five anaesthetized rats scanned using [C-11] SCH 23390, a marker of dopamine DI receptors. The integrity of the results was maintained between 2D and 3D data sets, though in 3D there was a significant reduction in the standard error of the fitted parameter. The results demonstrate that, with regard to sensitivity, there are significant gains in the physical performance of this tomograph when operating in 3D compared to 2D mode and that the quantification of PET studies of small animals using the 3Ddata reflects this.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:10:17