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Titolo:
MUCOLYTIC TREATMENT WITH N-ACETYLCYSTEINE L-LYSINATE METERED-DOSE INHALER IN DOGS - AIRWAY EPITHELIAL FUNCTION CHANGES
Autore:
TOMKIEWICZ RP; APP EM; COFFINER M; FOSSION J; MAES P; KING M;
Indirizzi:
UNIV ALBERTA,HERITAGE MED RES CTR 173,PULM & CELL BIOL RES GRP EDMONTON T6G 2S2 AB CANADA UNIV ALBERTA,HERITAGE MED RES CTR 173,PULM & CELL BIOL RES GRP EDMONTON T6G 2S2 AB CANADA GSF MUNICH,ENVIRONM & HLTH RES CTR MUNICH GERMANY SMB GALEPHAR,DEPT R&D BRUSSELS BELGIUM
Titolo Testata:
The European respiratory journal
fascicolo: 1, volume: 7, anno: 1994,
pagine: 81 - 87
SICI:
0903-1936(1994)7:1<81:MTWNLM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACHEAL MUCUS; RESPIRATORY MUCUS; CILIARY TRANSPORT; FROG PALATE; VISCOELASTICITY; CLEARANCE; RHEOLOGY; MODEL; COUGH;
Keywords:
DOGS; MUCOCILIARY CLEARANCE; MUCOLYTIC; MUCUS VISCOELASTICITY; TRANSEPITHELIAL POTENTIAL DIFFERENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Tomkiewicz et al., "MUCOLYTIC TREATMENT WITH N-ACETYLCYSTEINE L-LYSINATE METERED-DOSE INHALER IN DOGS - AIRWAY EPITHELIAL FUNCTION CHANGES", The European respiratory journal, 7(1), 1994, pp. 81-87

Abstract

N-acetylcysteine L-lysinate Nacystelyn(R) (L-NAC) is a newly synthesized mucolytic agent, of which the action in vivo has not been well defined. In six healthy mongrel dogs, the theological properties of mucus, its mucociliary and cough clearability, and the transepithelial potential difference (PD) of the tracheobronchial epithelium were evaluated after placebo and L-NAC metered dose inhaler (MDI) aerosols. The principal index of mucus rigidity, log G, decreased at all airway sites with L-NAC administration, ie. the mucus became less rigid and more deformable (the overall change in G was 0.29 log units, i.e. ca. twofold decrease). The viscoelasticity-derived mucus transportability parameters, mucociliary (MCI) and cough (CCI) clearability indices, increased with L-NAC MDI, particularly CCI, which pre diets the effect of mucus theology on cough clearability. PD increased significantly with L-NAC administration at all measurement sites, which appears to be a noveleffect for a direct acting mucolytic agent. Tracheal mucus linear velocity (TMV) increased after L-NAC compared with placebo, as did the normalized frog palate transport rate (NFPTR). The increase in NFPTR wasgreater than that predicted from the mucus rheological properties alone, suggesting that L-NAC still resident in the collected mucus stimulated the frog palate cilia. The index of mucus flux, the collection rate in mg min(-1), was higher with L-NAC compared with placebo. From our results, we conclude that L-NAC shows potential benefit in terms of improving mucus theological properties and clearability. It may act, in part, by stimulating the fresh secretion of mucus of lower viscoelasticity. The stimulation of mucociliary clearance could be related to ion flux changes, as indicated by the increase in PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:14:16