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Titolo:
NEUTRALIZATION EPITOPES ON HIV PSEUDOTYPED WITH HTLV-I - CONSERVATIONOF CARBOHYDRATE EPITOPES
Autore:
SORENSEN AMM; NIELSEN C; ARENDRUP M; CLAUSEN H; NIELSEN JO; OSINAGA E; ROSETO A; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK STATENS SERUM INST,DEPT VIROL COPENHAGEN DENMARK DENT COLL,DEPT ORAL DIAGNOST COPENHAGEN DENMARK UNIV TECHNOL COMPIEGNE,DICA COMPIEGNE FRANCE
Titolo Testata:
Journal of acquired immune deficiency syndromes
fascicolo: 2, volume: 7, anno: 1994,
pagine: 116 - 123
SICI:
0894-9255(1994)7:2<116:NEOHPW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CELL LEUKEMIA-VIRUS; HUMAN-ENDOTHELIAL CELLS; CD4-INDEPENDENT INFECTION; ENZYMATIC AMPLIFICATION; HOMOSEXUAL MEN; GLIAL-CELLS; ANTIBODIES; TYPE-1; AIDS;
Keywords:
HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T LYMPHOTROPIC VIRUS TYPE I; HUMAN IMMUNODEFICIENCY VIRUS PSEUDOTYPES; NEUTRALIZATION EPITOPES; PEPTIDES; CARBOHYDRATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A.M.M. Sorensen et al., "NEUTRALIZATION EPITOPES ON HIV PSEUDOTYPED WITH HTLV-I - CONSERVATIONOF CARBOHYDRATE EPITOPES", Journal of acquired immune deficiency syndromes, 7(2), 1994, pp. 116-123

Abstract

One mechanism for expanding the cellular tropism of human immunodeficiency virus (HIV) in vitro is through formation of phenotypically mixed particles (pseudotypes) with human T lymphotropic virus type I (HTLV-I). In this study we found that pseudotypes allow penetration of HIV particles into CD4-negative cells, previously nonsusceptible to HIV infection. The infection of CD4-negative cells with pseudotypes could beblocked with anti-HTLV-I serum but failed to be significantly inhibited with anti-HIV serum or a V-3-neutralizing anti-gp120 monoclonal antibody. This may represent a possibility for pseudotypes to escape neutralization by the immune system in vivo. Previous reports have suggested that carbohydrate structures may be conserved neutralization epitopes on retroviruses. In this study, the neutralizing capacity of lectins and anti-carbohydrate monoclonal antibodies was found to block infection by cell-free pseudotypes in CD4-negative cells. We suggest that although viral cofactors might expand the tropism of HIV in vivo, HIV and HTLV-I seem to induce common carbohydrate neutralization epitopes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:07:23