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Titolo:
ANTAGONISM OF THE PLATELET 5HT(2) RECEPTOR IN THE PRESENCE OF THROMBOLYSIS
Autore:
BELCHER PR; DRAKEHOLLAND AJ; NOBLE MIM;
Indirizzi:
CHARING CROSS & WESTMINSTER MED SCH,369 FULHAM RD LONDON SW10 9NH ENGLAND
Titolo Testata:
International journal of cardiology
fascicolo: 1, volume: 43, anno: 1994,
pagine: 11 - 20
SICI:
0167-5273(1994)43:1<11:AOTP5R>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE CORONARY-ARTERIES; ACUTE MYOCARDIAL-INFARCTION; CYCLIC FLOW VARIATIONS; PLASMINOGEN-ACTIVATOR; SEROTONIN; ASPIRIN; THROMBOSIS; AGGREGATION; REOCCLUSION; INHIBITION;
Keywords:
PLATELET; CORONARY ARTERY; SEROTONIN; THROMBOSIS; THROMBOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
P.R. Belcher et al., "ANTAGONISM OF THE PLATELET 5HT(2) RECEPTOR IN THE PRESENCE OF THROMBOLYSIS", International journal of cardiology, 43(1), 1994, pp. 11-20

Abstract

Thrombolysis of coronary arterial thrombi is often accompanied by occlusion due to continued platelet thrombosis. We modified the Felts' model of intracoronary thrombosis (critical stenosis with endothelial damage) to produce up to 35-min occlusions of the circumflex coronary artery in seven open-chest anaesthetised dogs. Administration of recombinant plasminogen activator (rtPA 200 mu g.kg(-1) bolus plus 1 mg.kg(-1).h(-1) infusion), without heparin or aspirin, always produced effective thrombolysis. Fibrinogen decreased (P < 0.05), thrombin time increased (P < 0.025), bleeding time trebled (P < 0.025) and initial arterial patency was achieved. Addition of a selective 5HT(2) antagonist, increased coronary blood flow (P < 0.01) and reduced rethrombosis rate (P< 0.025), but did not affect coagulation or bleeding. The time the vessel spent occluded was significantly decreased (P < 0.01) and correlated with the fibrinogen level (r=0.97, P < 0.01), thereby implying thepresence of fibrin within the thrombus. After rt-PA was withdrawn, bleeding time and fibrinogen level normalised within 30 and 60 min, respectively, but full coronary patency was maintained. Thus, when rt-PA alone had produced full thrombolysis, 5HT(2) antagonism prevented intracocornary thrombosis without additional bleeding complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:48:11