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Titolo:
APPETITE AND THE REGULATION OF BODY-COMPOSITION
Autore:
WEIGLE DS;
Indirizzi:
UNIV WASHINGTON,HARBORVIEW MED CTR,SCH MED,DEPT MED,ZA-24,325 9TH AVESEATTLE WA 98104
Titolo Testata:
The FASEB journal
fascicolo: 3, volume: 8, anno: 1994,
pagine: 302 - 310
SICI:
0892-6638(1994)8:3<302:AATROB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATURE FEMALE RATS; OVERFED OBESE RATS; ADIPOSE-TISSUE; FOOD-INTAKE; ENERGY-EXPENDITURE; PARABIOTIC RATS; METABOLIC RESPONSE; FEEDING-BEHAVIOR; WEIGHT-LOSS; FAT;
Keywords:
OBESITY; BODY WEIGHT REGULATION; FOOD INTAKE; ENERGY BALANCE; ADIPOSE TISSUE; PARABIOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Weigle, "APPETITE AND THE REGULATION OF BODY-COMPOSITION", The FASEB journal, 8(3), 1994, pp. 302-310

Abstract

Stability of body composition requires that energy intake equals energy expenditure when integrated over prolonged periods. As recent humanstudies have failed to demonstrate active changes in energy expenditure with changes in body composition, it is likely that energy intake is continually adjusted to preserve a constant total adipose tissue mass. If adipose tissue mass is regulated directly, then there must be some input reflecting this quantity to the central nervous system for the purpose of making corrective changes in appetite when total body fatcontent fluctuates. The nature of this input has been examined in a variety of animal experiments involving induced weight change, lipectomy, plasma transfer from obese or satiated animals to hungry animals, and parabiosis between obese and lean animals. The bulk of evidence suggests that the plasma level of one or more currently unidentified stable circulating molecules increases in proportion to total body fat content and augments the effect of meal-related satiety signals in the central nervous system. The implications of this adipose tissue-related satiety factor for the pathogenesis of obesity, and the possible nature of the factor are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:29:28