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Titolo:
ROLE OF GASTRIC GLANDULAR MUCOSAL ENERGY-METABOLISM IN COLD-RESTRAINTGASTRIC LESION FORMATION
Autore:
KOO MWL; CHO CH; OGLE CW;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHARMACOL,5 SASSOON RD,POKFULAM RD HONG KONG HONG KONG
Titolo Testata:
Archives internationales de pharmacodynamie et de therapie
, volume: 326, anno: 1993,
pagine: 84 - 94
SICI:
0003-9780(1993)326:<84:ROGGME>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-ANTAGONIST VERAPAMIL; VASCULAR SMOOTH-MUSCLE; ACID-SECRETION; STRESS ULCER; MECHANISM; HYPOTHERMIA; SHOCK; ATP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.W.L. Koo et al., "ROLE OF GASTRIC GLANDULAR MUCOSAL ENERGY-METABOLISM IN COLD-RESTRAINTGASTRIC LESION FORMATION", Archives internationales de pharmacodynamie et de therapie, 326, 1993, pp. 84-94

Abstract

The effects of cold and restraint and of some of the antiulcer drugs on adenosine nucleotide content in the gastric glandular mucosa were examined. A bioluminescence technique was used to measure the amount ofATP and its metabolites in gastric mucosal tissue. Cold-restraint produced gastric lesions and increased the gastric mucosal ATP. Verapamilpretreatment attenuated these lesions and further intensified the ATPincrease in a dose-related manner. The ATP/ADP ratio and the Atkinsonindex were also elevated. Calcium gluconate produced similar effects. Atropine or EGTA pretreatment protected or worsened the gastric lesion, respectively, but did not have any influence on the changes in mucosal energy metabolism. Ranitidine pretreatment lessened the lesion formation but had no influence on the nucleotide content. These findings indicate that the metabolic rate of the gastric mucosa is suppressed during cold-restraint conditions; this depression is probably due to hypothermia and reduction of mucosal metabolism. The lesion-protecting mechanisms of the drugs do not seem to be mediated through their effects on mucosal energy metabolism. The oxygen- and ATP-sparing effects ofverapamil may contribute partly to its gastro-protective effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 02:09:45