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Titolo:
ONTOGENY OF [I-125] IODOCYANOPINDOLOL-LABELED 5-HYDROXYTRYPTAMINE(1B)-BINDING SITES IN THE RAT CNS
Autore:
PRANZATELLI MR; GALVAN I;
Indirizzi:
CHILDRENS RES INST,CTR NEUROSCI,MOVEMENT DISORDER PHARMACOL LAB,111 MICHIGAN AVE NW WASHINGTON DC 20010 GEORGE WASHINGTON UNIV,DEPT NEUROL WASHINGTON DC 00000 GEORGE WASHINGTON UNIV,DEPT PEDIAT WASHINGTON DC 20052 GEORGE WASHINGTON UNIV,DEPT PHARMACOL WASHINGTON DC 20052
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 167, anno: 1994,
pagine: 166 - 170
SICI:
0304-3940(1994)167:1-2<166:OO[I5>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1 RECEPTOR AGONIST; 5-HYDROXYTRYPTAMINE-1B RECEPTORS; I-125 IODOCYANOPINDOLOL; SEROTONIN RECEPTOR; BRAIN MEMBRANES; RU-24969; )H-3>5-HYDROXYTRYPTAMINE; INHIBITION; DOPAMINE; BEHAVIOR;
Keywords:
5-HT1B SITE; ONTOGENY; SEROTONIN; RU 24969;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Pranzatelli e I. Galvan, "ONTOGENY OF [I-125] IODOCYANOPINDOLOL-LABELED 5-HYDROXYTRYPTAMINE(1B)-BINDING SITES IN THE RAT CNS", Neuroscience letters, 167(1-2), 1994, pp. 166-170

Abstract

Little is known about the ontogeny of the 5-hydroxytryptamine(1B) (5-HT1B) receptor, a putative terminal autoreceptor in the CNS. To learn more about the regional development of 5-HT1B sites and how early these sites may become functional, we studied [I-125]iodocyanopindolol ([125(I)]ICYP)labelled central 5-HT1B sites in developing postnatal rat brain and spinal cord. Significant ontogenic changes in B-max were found in neocortex, hippocampus, striatum and brainstem. Maximum binding-site density was reached by 21 days in hippocampus and cortex, but not until 28 days in striatum. The rank order of binding site density changed with rat age, but B-max was consistently high in brainstem and lowin cerebellum. The percent increases B-max also varied with brain region, ranging from a 2-fold increase in brainstem up to 8-fold increases in cortex and striatum. In competition studies, the K-1 for 5-HT andfor RU 24969 was the same in 5-day-old and adult rat brain. These data indicate regional differences in theontogeny of 5-HT1B-binding sitesand suggest that 5-HT1B receptors are functional early in the postnatal period.

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Documento generato il 30/11/20 alle ore 05:38:30