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Titolo:
EVENT-RELATED POTENTIAL AND CLINICAL CORRELATES OF NEURODYSFUNCTION IN OBSESSIVE-COMPULSIVE DISORDER
Autore:
TOWEY J; BRUDER G; TENKE C; LEITE P; DECARIA C; FRIEDMAN D; HOLLANDER E;
Indirizzi:
NEW YORK STATE PSYCHIAT INST & HOSP,DEPT BIOPSYCHOL,722 W 168 ST NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,BIOL STUDIES PROGRAM NEW YORK NY 00000 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT MED GENET NEW YORK NY 00000
Titolo Testata:
Psychiatry research
fascicolo: 2, volume: 49, anno: 1993,
pagine: 167 - 181
SICI:
0165-1781(1993)49:2<167:EPACCO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE METABOLIC RATES; META-CHLOROPHENYLPIPERAZINE; NEUROENDOCRINE RESPONSES; EVOKED-POTENTIALS; RELIABILITY; DEPRESSION; ATTENTION; DIAGNOSIS; FEATURES; VALIDITY;
Keywords:
ELECTROPHYSIOLOGY; ANXIETY DISORDER; CORTICAL AROUSAL; NEUROLOGICAL SOFT SIGNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
J. Towey et al., "EVENT-RELATED POTENTIAL AND CLINICAL CORRELATES OF NEURODYSFUNCTION IN OBSESSIVE-COMPULSIVE DISORDER", Psychiatry research, 49(2), 1993, pp. 167-181

Abstract

The current study confirmed with increased sample sizes our preliminary findings of event-related potential (ERP) abnormalities in obsessive-compulsive disorder (OCD) (Towey et al., 1990) and examined their relationship to symptom severity, treatment response, and neurological soft signs. Unmedicated patients (n = 17) showed larger negativities inN200 and slow wave regions than normal control subjects (n = 16) to correctly detected auditory ''oddball'' stimuli. N200 amplitude was larger over left than right hemispheres of OCD patients, but not normal control subjects. Greater N200 amplitude correlated with less severe obsessions, better response to subsequent treatment with serotonin reuptake blockers, and fewer neurological soft signs in OCD. With increasedtask difficulty, N200 and P300 latencies lengthened for normal subjects, but not for OCD patients. The abnormal ERP pattern in OCD supportshypotheses of cortical hyperarousal and overfocused attention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:49:37