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Titolo:
DOSE-DEPENDENT AND TIME-DEPENDENT CARDIOVASCULAR-RESPONSES INDUCED BYETHANOL
Autore:
BRACKETT DJ; GAUVIN DV; LERNER MR; HOLLOWAY FA; WILSON MF;
Indirizzi:
UNIV OKLAHOMA,HLTH SCI CTR,DEPT SURG,POB 26901 OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PSYCHIAT & BEHAV SCI OKLAHOMA CITY OK73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT MED OKLAHOMA CITY OK 00000 UNIV OKLAHOMA,HLTH SCI CTR,DEPT ANESTHESIOL OKLAHOMA CITY OK 00000 VET AFFAIRS MED CTR OKLAHOMA CITY OK 00000
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 268, anno: 1994,
pagine: 78 - 84
SICI:
0022-3565(1994)268:1<78:DATCIB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL SMOOTH-MUSCLE; MYOCARDIAL CONTRACTILITY; AUTONOMIC BLOCKADE; ALCOHOL; ACETALDEHYDE; DEPRESSION; RATS; PERFORMANCE; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Brackett et al., "DOSE-DEPENDENT AND TIME-DEPENDENT CARDIOVASCULAR-RESPONSES INDUCED BYETHANOL", The Journal of pharmacology and experimental therapeutics, 268(1), 1994, pp. 78-84

Abstract

Four groups of male Sprague-Dawley rats (10/group) were instrumented to permit access to venous and arterial blood and comprehensive cardiovascular measurements for 4 h after intragastric administrations of water or 2, 4 or 6 g/kg of ethanol. Maximum blood concentrations for each increasing dose occurred within 45 min after ethanol attaining peaksof 63 +/- 8, 103 +/- 11 and 221 +/- 33 mg/d, respectively. Cardiac outputs were significantly lower than the control group beginning at 15 min for 4 and 6 g/kg and at 120 mins for 2 g/kg with similar effects on stroke volume for the three doses. Systemic vascular resistance and heart rate were consistently increased throughout the 4 h for the 6 g/kg group. There was a delayed mean arterial blood pressure decrease inthe 6 g/kg group beginning at 120 min after ethanol with significant effects in the 4 g/kg group at 60 and 120 min. Decreased central venous pressure and respiration rate prevailed during the 4 h after 6 g/kg. Blood glucose concentrations were elevated at 60 min after 6 g/kg andat 240 min for all doses. However, blood temperatures were consistently lower than the control group after all three doses beginning 45 minafter the drug. These data demonstrate that ethanol evokes cardiovascular, respiratory and metabolic changes that are both dose- and time-dependent. Cardiac output and systemic vascular resistance are significantly affected suggesting a marked alteration of peripheral blood flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:08:26