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Titolo:
COMPARISON OF PD-145065 AND RO 46-2005 AS ANTAGONISTS OF CONTRACTIONSOF GUINEA-PIG AIRWAYS INDUCED BY ENDOTHELIN-1 OR IRL-1620
Autore:
BATTISTINI B; WARNER TD; FOURNIER A; VANE JR;
Indirizzi:
ST BARTHOLOMEWS HOSP,COLL MED,WILLIAM HARVEY RES INST,CHARTERHOUSE SQLONDON EC1M 6BQ ENGLAND ST BARTHOLOMEWS HOSP,COLL MED,WILLIAM HARVEY RES INST LONDON EC1M 6BQENGLAND INST NATL RECH SCI SANTE MONTREAL H9R 1G6 PQ CANADA
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 252, anno: 1994,
pagine: 341 - 345
SICI:
0014-2999(1994)252:3<341:COPAR4>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; IRL-1620; AGONIST;
Keywords:
IRL 1620; PD 145065; RO 46-2005; ENDOTHELIN ET(A)/ET(B) NONSELECTIVE RECEPTOR ANTAGONIST;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
B. Battistini et al., "COMPARISON OF PD-145065 AND RO 46-2005 AS ANTAGONISTS OF CONTRACTIONSOF GUINEA-PIG AIRWAYS INDUCED BY ENDOTHELIN-1 OR IRL-1620", European journal of pharmacology, 252(3), 1994, pp. 341-345

Abstract

Cumulative concentrations of endothelin-1 or IRL 1620 (Suc-[Glu(9),Ala(11,15)]endothelin-1-(8-21)) an endothelin ET(B) receptor selective agonist were similarly potent in contracting guinea-pig upper bronchi, whereas endothelin-1 was more potent than IRL 1620 in contracting lungparenchymal strips. PD 145065 (10(-5) M and 10(-4) M), a non-selective endothelin ET(A)/ET(B) receptor antagonist (Ac-D-Bhg-L-Leu-L-Asp-L-Ile-L-Ile-L-Trp), significantly attenuated the contractions induced by endothelin-1 in either preparation whereas Ro 46-2005 (3 x 10(-5) M and 10(-4) M), a non-peptide non-selective receptor antagonist thoxy)-5-3-methoxy-phenoxy)-(benzenesulfonamide)), was without effect. PD 145065 (10(-6) M and 10(-5) M) also strongly inhibited contractions inducedby IRL 1620, whereas Ro 46-2005 caused much less antagonism. Thus, PD145065 is a more potent antagonist than Ro 46-2005 of contractions induced by endothelin-1 or IRL 1620 and mediated by endothelin ET(B) receptors in these guinea-pig airway preparations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:53:29