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Titolo:
INVOLVEMENT OF CENTRAL SEROTONERGIC PATHWAYS IN ANALGESIA ELICITED BYSALMON-CALCITONIN IN THE MOUSE
Autore:
COLADO MI; ORMAZABAL MJ; GOICOECHEA C; LOPEZ F; ALFARO MJ; MARTIN MI;
Indirizzi:
UNIV COMPLUTENSE,FAC MED,INST FARMACOL & TOXICOL,DEPT FARMACOL E-28040 MADRID SPAIN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 252, anno: 1994,
pagine: 291 - 297
SICI:
0014-2999(1994)252:3<291:IOCSPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITE DISTRIBUTION; ANTINOCICEPTIVE ACTIVITY; PARA-CHLOROAMPHETAMINE; BRAIN; MORPHINE; SYSTEM; RAT; 5-HYDROXYTRYPTAMINE; PAIN; MICE;
Keywords:
CALCITONIN; ANALGESIA; 5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); P-CHLOROPHENYLALANINE; P-CHLOROAMPHETAMINE; ACETIC ACID TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Colado et al., "INVOLVEMENT OF CENTRAL SEROTONERGIC PATHWAYS IN ANALGESIA ELICITED BYSALMON-CALCITONIN IN THE MOUSE", European journal of pharmacology, 252(3), 1994, pp. 291-297

Abstract

The contribution of central serotonergic pathways to the analgesic activity induced by salmon calcitonin in the writhing test was investigated. Salmon calcitonin was administered to mice after lesioning of theascending and descending serotonergic pathways by means of i.p. administration of p-chloroamphetamine (40 mg/kg, for 2 days) or p-chlorophenylalanine (300 mg/kg, for 3 days). The analgesic effect induced by salmon calcitonin at the doses of 10 and 20 IU/kg was not evident in mice previously treated with p-chloroamphetamine or p-chlorophenylalanine. However, the analgesic effect of salmon calcitonin 40 IU/kg was not significantly modified by p-chloroamphetamine or p-chlorophenylalaninepretreatment. Salmon calcitonin did not alter the depletion of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid after p-chloroamphetamine or p-chlorophenylalanine administration. Similarly, this hormone did not change the NSD 1015-induced accumulation of 5-hydroxytryptophan or the tranylcypromine-induced accumulation of 5-HT. These results indicate that although salmon calcitonin does not influence the synthesis and metabolism of 5-HT, it does require the integrity of the serotonergic system in order to cause analgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:31:01