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Titolo:
NEONATAL THYMECTOMY DIMINISHES RENAL IGA DEPOSITION IN IGA NEPHROPATHY-PRONE DDY MICE
Autore:
NAGASAWA R; MITARAI T; UTSUNOMIYA Y; YOSHIDA H; KITAMURA M; YAMURA W; MARUYAMA N; ISODA K; SAKAI O;
Indirizzi:
SAITAMA MED SCH,SAITAMA MED CTR,DEPT INTERNAL MED 4,1981 KAMODATSUJIDO KAWAGOE SAITAMA 350 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED TOKYO JAPAN TOKYO WOMENS MED COLL,CTR KIDNEY,DEPT MED TOKYO TOKYO JAPAN TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PATHOL TOKYO TOKYO JAPAN
Titolo Testata:
Nephron
fascicolo: 3, volume: 66, anno: 1994,
pagine: 326 - 332
SICI:
0028-2766(1994)66:3<326:NTDRID>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; POLYMERIC IGA; GLOMERULONEPHRITIS; DISEASE; NEPHRITIS; CELLS;
Keywords:
DDY MOUSE; IGA NEPHROPATHY; NEONATAL THYMECTOMY; MESANGIAL IGA DEPOSITION; CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R. Nagasawa et al., "NEONATAL THYMECTOMY DIMINISHES RENAL IGA DEPOSITION IN IGA NEPHROPATHY-PRONE DDY MICE", Nephron, 66(3), 1994, pp. 326-332

Abstract

To understand the role of thymus-derived T cells in the development of IgA nephropathy (IgAN), we performed neonatal thymectomies on ddY mice, in which this disease occurs spontaneously. Although these thymectomized mice developed a renal lesion closely resembling that typical of IgAN, the extent of their mesangial IgA deposition was significantlymilder than in control sham-operated mice. The immunological mechanisms responsible for curbing this mesangial deposition of IgA were then analyzed. The percentage of splenic T cells and the magnitude of mitogenic responses both decreased markedly in thymectomized compared with control mice. These results suggested the hypofunction of thymus-derived T cells. However, serum IgA levels were almost identical in both groups. Furthermore, sera from both groups contained similar amounts of macromolecular IgA, of the type formerly eluted from the affected glomeruli of patients with IgAN. These results strongly indicate that thymus-derived T cells or their products determine the amount of IgA deposited in the kidneys of ddY mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:58:00