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Titolo:
IMMUNOLOGICAL FINDINGS AND THYROID-FUNCTION OF UNTREATED GRAVES-DISEASE PATIENTS WITH UNDETECTABLE TSH-BINDING INHIBITOR IMMUNOGLOBULIN
Autore:
MUKUTA T; TAMAI H; OSHIMA A; MORITA T; MATSUBAYASHI S; FUKATA S; KUMA K;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT PSYCHOSOMAT MED,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812 JAPAN KYUSHU UNIV,FAC MED,DEPT PSYCHOSOMAT MED,HIGASHI KU FUKUOKA 812 JAPAN KUMA HOSP KOBE 650 JAPAN
Titolo Testata:
Clinical endocrinology
fascicolo: 2, volume: 40, anno: 1994,
pagine: 215 - 219
SICI:
0300-0664(1994)40:2<215:IFATOU>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN RECEPTOR ANTIBODIES; STIMULATING IMMUNOGLOBULINS; RADIORECEPTOR ASSAY; PRACTICAL ASSAY; FOLLOW-UP; LYMPHOCYTES; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Mukuta et al., "IMMUNOLOGICAL FINDINGS AND THYROID-FUNCTION OF UNTREATED GRAVES-DISEASE PATIENTS WITH UNDETECTABLE TSH-BINDING INHIBITOR IMMUNOGLOBULIN", Clinical endocrinology, 40(2), 1994, pp. 215-219

Abstract

OBJECTIVE TSH-binding inhibitory immunoglobulin (TBII) is undetectable in about 10% of untreated Graves' disease patients, but the clinicalcharacteristics and immunological significance of this finding are unknown. In this study we evaluated the clinical characteristics of TBIInegative Graves' disease. PATIENTS We examined TBII in 1048 untreatedpatients at Kuma hospital from 1986 to 1990 and found 69 TBII undetectable patients (12 men and 57 women, mean age +/- SEM 35 +/- 2 years, group A). MEASUREMENTS We compared the clinical characteristics and immunological findings of group A with 57 untreated Tell detectable Graves' patients who were selected randomly (11 men and 46 women, mean age+/- SEM 40 +/- 2 years, group B). T4, TSH, FT4, FT3, I-123 thyroid uptake, TBII, thyroid stimulating antibodies (TSAb) and the volume of the thyroid using ultrasonography were measured at the first visit. RESULTS Serum T4, FT4 and FT3 levels in group A were significantly Tower than those in group B (P < 0.001). The values of TSAb in group A were significantly lower than those in group B (593 +/- 67 (mean +/- SE) vs 2143 +/- 280%, respectively, P < 0.001). The I-123 thyroid uptake in group A was significantly lower than that in group B (53.1 +/- 1.1 vs 61.4 +/- 1.4%, respectively, P < 0.01). The thyroid volume in group A was significantly smaller than that in group B (39.1 +/- 3.0 vs 51.3 +/- 3.3 mi, respectively, P < 0.01). TSAb was undetectable in about 10% (6) of the TBII negative untreated Graves' patients at their first visit. CONCLUSION In the present study, untreated TBII negative patients with Graves' disease were characterized by mild elevation of thyroid hormones, mildly elevated I-123 uptake, weak TSAb activities and small goitres. The finding of both TBII and TSAb negative titres in untreated Graves' disease patients was also confirmed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:10:02