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Titolo:
DIRECT AND INDIRECT RETINOHYPOTHALAMIC PROJECTIONS TO THE SUPRAOPTIC NUCLEUS IN THE FEMALE ALBINO-RAT
Autore:
LEVINE JD; ZHAO XS; MISELIS RR;
Indirizzi:
UNIV PENN,SCH VET MED,DEPT ANIM BIOL,3800 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,SCH VET MED,DEPT ANIM BIOL PHILADELPHIA PA 19104
Titolo Testata:
Journal of comparative neurology
fascicolo: 2, volume: 341, anno: 1994,
pagine: 214 - 224
SICI:
0021-9967(1994)341:2<214:DAIRPT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS; CENTRAL-NERVOUS-SYSTEM; MAIN OLFACTORY-BULB; PSEUDORABIES VIRUS; BRAIN-STEM; SUPRACHIASMATIC NUCLEUS; TRANSNEURONAL TRANSPORT; RETINAL PROJECTIONS; VISUAL-SYSTEM; CHOLERA-TOXIN;
Keywords:
CIRCADIAN RHYTHMS; PSEUDORABIES VIRUS; FLUID BALANCE; HOMEOSTASIS; DRINKING BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Levine et al., "DIRECT AND INDIRECT RETINOHYPOTHALAMIC PROJECTIONS TO THE SUPRAOPTIC NUCLEUS IN THE FEMALE ALBINO-RAT", Journal of comparative neurology, 341(2), 1994, pp. 214-224

Abstract

Earlier studies have shown that retinohypothalamic projections terminate extensively within the hypothalamus of the rat. Recently, we identified a light retinal projection to the supraoptic nucleus as well as a larger, well-focused projection resulting in a peri-supraoptic nucleus terminal field. In this study, we employed a double labeling methodwith cholera toxin conjugated to horseradish peroxidase (CT-HRP) and pseudorabies virus, a transsynaptic neural tracer, to evaluate retinorecipient neurons in both the supraoptic nucleus and peri-supraoptic nucleus terminal field. In addition, we looked for evidence that cells in the peri-supraoptic nucleus terminal field project into the supraoptic nucleus. Three strains of pseudorabies virus were compared. A direct retinosupraoptic nucleus circuit was confirmed with all three strains. Retinorecipient neurons in the peri-supraoptic nucleus terminal field were also confirmed. However, there was a strain-based difference in the identification of these neurons. The wild-type Becker strain labeled cells in the peri-supraoptic nucleus terminal field in a manner paralleling the early, intermediate and late stages of infection of thesuprachiasmatic nucleus. This parallel time course suggests that retinal ganglion cells terminate directly on cells in the peri-supraoptic nucleus terminal field. Conversely, the Bartha and PRV-91 strains showed appreciable labeling of peri-supraoptic neurons only at long survival times. This longer time course suggests that these mutant strains label neurons in the peri-supraoptic nucleus terminal field indirectly,after passing through additional neurons. In addition, experiments with monocular injection of CT-HRP and posterior pituitary injection of pseudorabies virus showed retrogradely labeled second-order cells in the peri-supraoptic nucleus amidst the CT-HRP labeled terminal field ofthe retinohypothalamic tract. These results demonstrate a direct projection from the retina to the supraoptic nucleus and provide evidence for an indirect circuit from the retina to the supraoptic nucleus via neurons located in the peri-supraoptic nucleus terminal field. The strain-based differences imply that those retinal ganglion cells that project to the peri-supraoptic nucleus terminal field differ from those that project to the suprachiasmatic nucleus. In addition, these resultssuggest a neuroanatomic basis for photic effects on physiological mechanisms that are not mediated by the circadian timing system. (C) 1994Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:33:23