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Titolo:
A PROTECTIVE ASSOCIATION BETWEEN THE HLA-A2 ANTIGEN AND NASOPHARYNGEAL CARCINOMA IN US CAUCASIANS
Autore:
BURT RD; VAUGHAN TL; NISPEROS B; SWANSON M; BERWICK M;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL,1124 COLUMBIA ST SEATTLE WA 98105 FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL SEATTLE WA 98105 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 FRED HUTCHINSON CANC RES CTR,DEPT HUMAN IMMUNOGENET SEATTLE WA 00000 MICHIGAN STATE UNIV,CTR COMPREHENS BREAST CANC E LANSING MI 00000 MICHIGAN CANC FDN DETROIT MI 00000 YALE UNIV,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06520 CANC PREVENT RES INST NEW YORK NY 00000
Titolo Testata:
International journal of cancer
fascicolo: 4, volume: 56, anno: 1994,
pagine: 465 - 467
SICI:
0020-7136(1994)56:4<465:APABTH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Burt et al., "A PROTECTIVE ASSOCIATION BETWEEN THE HLA-A2 ANTIGEN AND NASOPHARYNGEAL CARCINOMA IN US CAUCASIANS", International journal of cancer, 56(4), 1994, pp. 465-467

Abstract

Analyzing data from Caucasians participating in a multicentered population-based case-control study of nasopharyngeal carcinoma and HLA type in the US, we found persons with the AZ antigen to have a significantly lower risk than those with other antigens at the A locus [odds ratio (OR). 0.46; 95% confidence interval (CI), 0.21-0.96]. The protective association was stronger among presumptive homozygotes for AZ. Similar results were obtained when cases were compared with US Caucasians typed either as part of the Collaborative Transplant Study, or by the 9th International Histocompatibility Workshop. These results are supported by a statistical summary of odds ratios for AZ from a number of previous studies in non-Chinese (summary OR, 0.69; 95% CI, 0.54-0.88). The odds ratio for patients with squamous-cell carcinomas was 0.56; among 7 patients with undifferentiated tumors the OR was 0.14. Results from in vitro studies of immune response to Epstein-Barr virus have found that the HLA-AZ antigen efficiently presents the EBV gene product LMP-2, which has been detected in NPC tumor cells. This offers a rationale for the observed protective association between the HLA-AZ antigen and nasopharyngeal carcinoma. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:44:24