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Titolo:
TOXICITY OF MIXTURES OF ORGANIC-CHEMICALS TO MICROORGANISMS
Autore:
NIRMALAKHANDAN N; ARULGNANENDRAN V; MOHSIN M; SUN B; CADENA F;
Indirizzi:
NEW MEXICO STATE UNIV,DEPT CIVIL AGR & GEOL ENGN LAS CRUCES NM 88003
Titolo Testata:
Water research
fascicolo: 3, volume: 28, anno: 1994,
pagine: 543 - 551
SICI:
0043-1354(1994)28:3<543:TOMOOT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAPHNIA-MAGNA; FISH TOXICITY; ACUTE LETHAL; QSAR;
Keywords:
MIXTURE TOXICITY; QSAR MODEL; MICROBIAL ACTIVITY; MODELING JOINT EFFECTS; POLYTOX CULTURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
N. Nirmalakhandan et al., "TOXICITY OF MIXTURES OF ORGANIC-CHEMICALS TO MICROORGANISMS", Water research, 28(3), 1994, pp. 543-551

Abstract

Approaches developed by toxicologists in analyzing joint effects of two or more chemicals on fish were used to analyze and predict joint effects on microorganisms. Based on the results, the joint toxic effectsof the 50 chemicals tested in this study can be considered simply additive. A quantitative structure-activity relationship (QSAR) techniqueis proposed for predicting the concentrations of the components of a mixture that would cause 50% inhibition by joint action. The concentrations predicted by the proposed QSAR method are shown to agree well with those experimentally measured with r(2) = 0.8 at a level of significance, P = 0.0001.

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Documento generato il 06/07/20 alle ore 08:49:43