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Titolo:
TEMPORAL AND REGIONAL EXPRESSION OF PLACENTAL LACTOGEN-II MESSENGER-RIBONUCLEIC-ACID AND PROTEIN IN THE HAMSTER PLACENTA
Autore:
JONES MA; RENEGAR RH;
Indirizzi:
E CAROLINA UNIV,SCH MED,DEPT ANAT & CELL BIOL GREENVILLE NC 27858
Titolo Testata:
Biology of reproduction
fascicolo: 3, volume: 50, anno: 1994,
pagine: 581 - 592
SICI:
0006-3363(1994)50:3<581:TAREOP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROPHOBLAST GIANT-CELLS; GROWTH-HORMONE; CHORIONIC SOMATOMAMMOTROPIN; MOUSE PLACENTA; LOCALIZATION; FETAL; PREGNANCY; RAT; GONADOTROPIN; GESTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Jones e R.H. Renegar, "TEMPORAL AND REGIONAL EXPRESSION OF PLACENTAL LACTOGEN-II MESSENGER-RIBONUCLEIC-ACID AND PROTEIN IN THE HAMSTER PLACENTA", Biology of reproduction, 50(3), 1994, pp. 581-592

Abstract

The purpose of this investigation was to identify the cell types synthesizing hamster placental lactogen-II (haPL-II) in the chorioallantoic placenta. In addition, temporal changes in haPL-II mRNA expression, in placental mass, and in the proportion of haPL-II-containing cells per unit area were examined. Hamster PL-II mRNA expression was assessedby in situ hybridization and Northern and slot-blot analyses. Cells containing haPL-II protein were identified by immunocytochemical techniques. Placentae were recovered in the morning on Days 6, 8, 10, 12, and 14 of gestation and in the afternoon on Day 15. A single I kb haPL-II transcript was first detected on Day 10 of gestation. Hamster PL-II message increased to Day 14 and remained elevated on Day 15. Giant trophoblast cells (GTC) located in the trophospongium were the major source of haPL-II mRNA and protein, although GTC along the periphery of the placenta and in the labyrinth expressed haPL-II as well. Placental weight, trophospongium portion of placental weight, and number of haPL-II-immunostained GTC per unit of placental area increased between Days12 and 14 and remained elevated to Day 15. These observations indicate that an increased number of haPL-II-producing GTC is a major factor contributing to increased maternal haPL-II serum levels during pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:47:05