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Titolo:
IMMUNOHISTOLOGICAL LOCALIZATION OF CLUSTERIN IN THE MALE GENITAL-TRACT IN HUMANS AND MARMOSETS
Autore:
OBRYAN MK; MALLIDIS C; MURPHY BF; BAKER HWG;
Indirizzi:
ST VINCENTS HOSP,DEPT NEPHROL,51 VICTORIA PDE FITZROY VIC 3065 AUSTRALIA ST VINCENTS HOSP,DEPT NEPHROL FITZROY VIC 3065 AUSTRALIA UNIV MELBOURNE,ST VINCENTS HOSP,DEPT MED PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,ROYAL WOMENS HOSP PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Biology of reproduction
fascicolo: 3, volume: 50, anno: 1994,
pagine: 502 - 509
SICI:
0006-3363(1994)50:3<502:ILOCIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATED GLYCOPROTEIN-2 CLUSTERIN; RAT VENTRAL PROSTATE; MESSENGER-RIBONUCLEIC-ACID; RETE TESTIS FLUID; MOLECULAR-CLONING; SERTOLI CELLS; REPRODUCTIVE-SYSTEM; EPITHELIAL-CELLS; GENE-EXPRESSION; HUMAN PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Obryan et al., "IMMUNOHISTOLOGICAL LOCALIZATION OF CLUSTERIN IN THE MALE GENITAL-TRACT IN HUMANS AND MARMOSETS", Biology of reproduction, 50(3), 1994, pp. 502-509

Abstract

Clusterin is a multifunctional protein, first described in the reproductive tracts of the rat and the ram. It is produced by several cell types and exists in at least two differentially glycosylated forms. Theaim of this study was to extend knowledge of clusterin expression in the primate (human and marmoset) male reproductive tracts by means of clusterin-specific immunohistochemical techniques. In both normal and abnormal testicular tissue, clusterin was found in association with Sertoli cells, lumenal sperm, proacrosomal Golgi complexes, residual bodies, and degenerating germ cells. The major differences observed between the two groups were attributable primarily to morphological differences rather than to clusterin expression specifically. There was no correlation between testicular clusterin content and the cause and severity of spermatogenic disorders. Within normal epididymides, regional differences in clusterin staining similar to those reported in the rat were observed. The seminal vesicles contained large amounts of positive clusterin staining, whereas normal human prostate was completely negative. Low levels of clusterin expression were observed in the marmoset prostate. This study suggests that clusterin is an important and widespread product in the human and marmoset reproductive tracts and is likely to have a role in spermatogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:16:18