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Titolo:
COCAINE-INDUCED MICROVASCULAR SPASM IN YUCATAN MINIATURE SWINE - IN-VIVO AND IN-VITRO EVIDENCE OF SPASM
Autore:
NUNEZ BD; MIAO L; WANG YD; NUNEZ MM; SELLKE FW; ROSS JN; SUSULIC V; PAIK GY; CARROZZA JP; MORGAN JP;
Indirizzi:
BETH ISRAEL HOSP,DEPT MED,DIV CARDIOVASC,330 BROOKLINE AVE BOSTON MA 02215 BETH ISRAEL HOSP,DEPT MED,DIV CARDIOVASC BOSTON MA 02215 BETH ISRAEL HOSP,CHARLES A DANA RES INST BOSTON MA 02215 HARVARD UNIV,BETH ISRAEL HOSP,THORNDIKE LAB BOSTON MA 02215 BETH ISRAEL HOSP,DEPT RADIOL BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 00000 TUFTS UNIV,SCH VET MED N GRAFTON MA 00000 BOSTON UNIV,SCH MED,DEPT PATHOL BOSTON MA 02118
Titolo Testata:
Circulation research
fascicolo: 2, volume: 74, anno: 1994,
pagine: 281 - 290
SICI:
0009-7330(1994)74:2<281:CMSIYM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL CORONARY-ARTERIES; MYOCARDIAL-INFARCTION; BALLOON INJURY; FLOW VELOCITY; VASOCONSTRICTION; DOGS; HEART; MODEL; CIRCULATION; ANGIOPLASTY;
Keywords:
COCAINE; CORONARY BLOOD FLOW; CORONARY FLOW RESERVE; MICROCIRCULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Nunez et al., "COCAINE-INDUCED MICROVASCULAR SPASM IN YUCATAN MINIATURE SWINE - IN-VIVO AND IN-VITRO EVIDENCE OF SPASM", Circulation research, 74(2), 1994, pp. 281-290

Abstract

The purpose of the present study was to determine the maximal coronary flow reserve (CFR) before and after the administration of successivecocaine doses (0.1, 0.5, 3, and 7 mg/kg IV) for 2 minutes at 10-minute intervals in eight miniature swine. CFR was assessed by the administration of adenosine (0.03, 0.3, and 3 mg IC). Hemodynamic and flow measurements were performed 3 minutes after each dose. Coronary flow (CF)was measured with a Doppler-tipped wire in the proximal left anteriordescending coronary artery (LAD). Also, microvessels were dissected, and Vessel diameters were measured by a videoelectronic dimension analyzer. In vivo, LAD CF increased fourfold, CFR increased twofold, and coronary vascular resistance (CVR) decreased fourfold after the administration of adenosine. In contrast, LAD CF decreased threefold, CFR decreased onefold, and CVR increased sixfold 3 minutes after the administration of cocaine. Adenosine (3 mg) was repeated 4 minutes after the administration of cocaine, and LAD CF increased 1.4-fold, CVR increased2.5-fold, and CFR decreased onefold. Thus, adenosine partially reversed the potent cocaine constrictor effect. In vitro, 10(-9) mol/L cocaine decreased the diameter of the coronary microvessels from 129+/-12 to 127+/-12 mu m, and 10(-4) moL/L cocaine decreased coronary microvessel diameter to 114+/-15 mu m (P<.05). In conclusion cocaine in vivo decreases CFR, and consistent with the in vivo effect, cocaine in vitro produced constriction of vessels <200 mu m. These results indicate that cocaine can produce profound microvascular spasm. This may contribute to the ischemia/infarction reported in patients who abuse cocaine and who are subsequently found to have normal epicardial coronary arteries.

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Documento generato il 28/09/20 alle ore 10:18:48