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Titolo:
REGIONAL CEREBRAL BLOOD-FLOW IMAGING WITH TC-99M-BICISATE SPECT IN ASYMMETRIC PARKINSONS-DISEASE - STUDIES WITH AND WITHOUT CHRONIC DRUG-THERAPY
Autore:
MILETICH RS; QUARANTELLI M; DICHIRO G;
Indirizzi:
NIH,BLDG 10,RM 1C451 BETHESDA MD 20892 NINCDS,NEUROIMAGING BRANCH BETHESDA MD 00000
Titolo Testata:
Journal of cerebral blood flow and metabolism
, volume: 14, anno: 1994, supplemento:, 1
pagine: 190000106 - 190000114
SICI:
0271-678X(1994)14:<190000106:RCBIWT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-UTILIZATION; TECHNETIUM-99M L,L-ECD; OXYGEN-METABOLISM; LEVODOPA; TOMOGRAPHY; XE-133; DOPA; RAT;
Keywords:
ASYMMETRIC PARKINSONS DISEASE; BASAL GANGLIA PERFUSION; ETHYL CYSTEINATE DIMER; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Miletich et al., "REGIONAL CEREBRAL BLOOD-FLOW IMAGING WITH TC-99M-BICISATE SPECT IN ASYMMETRIC PARKINSONS-DISEASE - STUDIES WITH AND WITHOUT CHRONIC DRUG-THERAPY", Journal of cerebral blood flow and metabolism, 14, 1994, pp. 190000106-190000114

Abstract

Regional cerebral perfusion was assessed in six patients with asymmetric Parkinson's disease (PD) of mild to moderate severity and in six matched normal subjects using Tc-99m-bicisate single photon emission computed tomography (SPECT). Regional activity was normalized to whole-brain activity. Each subject was studied twice, separated by 15.2 +/- 9.2 and 18.0 +/- 4.8 days in normals and PD patients, respectively. There was low intrasubject scan-rescan variability in normals, with all regions showing an average intrasubject difference in repeat studies of< 3%. In PD patients after chronic oral antiparkinsonian drugs had been withdrawn, as compared with normal subjects, there was increased perfusion in the caudate and lenticular nuclei contralateral to the worst affected extremities. This increased basal ganglia perfusion was attenuated by chronic oral therapy. The clinical relevance of these changes is indicated by the high positive correlation between various measures of clinical PD severity and the lenticular perfusion. These differences in basal ganglia perfusion measured with Tc-99m-bicisate SPECT in mild to moderate, asymmetric PD may be secondary to increased metabolic demand resulting from alterations of synaptic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 18:35:49