Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INACTIVATION OF THE PORPHYROMONAS-GINGIVALIS FIMA GENE BLOCKS PERIODONTAL DAMAGE IN GNOTOBIOTIC-RATS
Autore:
MALEK R; FISHER JG; CALECA A; STINSON M; VANOSS CJ; LEE JY; CHO MI; GENCO RJ; EVANS RT; DYER DW;
Indirizzi:
UNIV OKLAHOMA,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,POB 26901 OKLAHOMA CITY OK 73190 SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT MICROBIOL BUFFALO NY 14214 SUNY BUFFALO,SCH DENT MED,DEPT ORAL BIOL BUFFALO NY 14214 SUNY BUFFALO,SCH ENGN & APPL SCI,DEPT CHEM ENGN BUFFALO NY 14214
Titolo Testata:
Journal of bacteriology
fascicolo: 4, volume: 176, anno: 1994,
pagine: 1052 - 1059
SICI:
0021-9193(1994)176:4<1052:IOTPFG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLACK-PIGMENTED BACTEROIDES; ACTINOMYCES-VISCOSUS; ESCHERICHIA-COLI; INSERTIONAL MUTAGENESIS; EPITHELIAL-CELLS; ADHERENCE; FIMBRIAE; ASACCHAROLYTICUS; PROTEIN; PORPHYROMONAS-(BACTEROIDES)-GINGIVALIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R. Malek et al., "INACTIVATION OF THE PORPHYROMONAS-GINGIVALIS FIMA GENE BLOCKS PERIODONTAL DAMAGE IN GNOTOBIOTIC-RATS", Journal of bacteriology, 176(4), 1994, pp. 1052-1059

Abstract

Fimbrial production by Porpyromonas gingivalis was inactivated by insertion-duplication mutagenesis, using the cloned gene for the P. gingivalis major fimbrial subunit protein, fimA. By several criteria, this insertion mutation rendered P. gingivalis unable to produce fimbrilin or an intact fimbrial structure. A nonfimbriated mutant, DPG3, hemagglutinated sheep erythrocytes normally and was unimpaired in the abilityto coaggregate with Streptococcus gor gordonii G9B. The cell surface hydrophobicity of DPG3 was also unaffected by the loss of fimbriae. However, DPG3 was significantly less able to bind to saliva-coated hydroxyapatite than mild-type P. gingivalis 381. This suggested that P. gingivalis fimbriae are important for adherence of the organism to saliva-coated oral surfaces. Further, DPG3 was significantly less able to cause periodontal bone loss in a gnotobiotic rat model of periodontal disease. These observations are consistent with other data suggesting that P. gingivalis fimbriae play an important role in the pathogenesis of human periodontal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:27:53