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Titolo:
BIS(DITHIOCARBAMATO) NITRIDO TC-99M RADIOPHARMACEUTICALS - A CLASS OFNEUTRAL MYOCARDIAL IMAGING AGENTS
Autore:
PASQUALINI R; DUATTI A; BELLANDE E; COMAZZI V; BRUCATO V; HOFFSCHIR D; FAGRET D; COMET M;
Indirizzi:
UNIV BOLOGNA,DIPARTIMENTO CHIM FIS & INORGAN,VIALE RISORGIMENTO 4 I-40136 BOLOGNA ITALY UNIV BOLOGNA,DIPARTIMENTO CHIM FIS & INORGAN I-40136 BOLOGNA ITALY CIS BIO INT GIF SUR YVETTE FRANCE CEA,DPTE,LRT BRUYERES CHATEL FRANCE CNRS,URA 1287 GRENOBLE FRANCE
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 2, volume: 35, anno: 1994,
pagine: 334 - 341
SICI:
0161-5505(1994)35:2<334:BNTR-A>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEXES; RADIOPHARMACEUTICALS; AMINES; CELLS; BOND;
Keywords:
MYOCARDIAL IMAGING AGENTS; TECHNETIUM-99M-BIS(DITHIOCARBAMATO) NITRIDO COMPOUNDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R. Pasqualini et al., "BIS(DITHIOCARBAMATO) NITRIDO TC-99M RADIOPHARMACEUTICALS - A CLASS OFNEUTRAL MYOCARDIAL IMAGING AGENTS", The Journal of nuclear medicine, 35(2), 1994, pp. 334-341

Abstract

The synthesis and biodistribution in various animal models (rat, dog,pig and monkey) of Tc-99m radiopharmaceuticals containing the Tc=N multiple bond are reported. Methods: The complexes are represented by the general formula (TcN)-Tc-99m(L)2, where L is the monoanionic form ofa dithiocarbamate ligand of the type [R(1)(R(2))-N-C(=S)S](-), and R(1) and R(2) are variable, lateral groups. The preparations were carried out, both as a liquid and freeze-dried formulation, through a simpleprocedure involving the initial reaction of [(TcO4)-Tc-99m](-) with S-methyl N-methyl dithiocarbazate [H2NN(CH3)C(=S)SCH3], in the presenceof tertiary phosphines or Sn2+ ion as reductants, followed by the addition of the sodium salt of the ligand (NaL) to afford the final product. The chemical identity of the resulting complexes was determined bycomparing their chromatographic properties with those of the corresponding Tc-99 analogs characterized by spectroscopic and x-ray crystallographic methods. The complexes are neutral and possess a distorted, square pyramidal geometry. Results: No decomposition of the complexes, in physiological solution, was observed over a period of 6 hr. Imaging and biodistribution studies demonstrated that these radiopharmaceuticals localize selectively in the myocardium of rats, dogs and primates, but that they failed to visualize the pig heart. The kinetics of heartuptake and clearance were studied in rats and dogs, and found to be strongly influenced by variation of the lateral R(1) and R2 groups. Conclusion: The high quality of myocardial images obtained in dogs and monkeys demonstrates that the derivative (TCN)-T-99m[E-t(EtO)NCS2](2) [(TCN)-T-99m(NOEt)] exhibits the most favorable distribution properties for further studies in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:32:09