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Titolo:
TIME-DEPENDENT CHANGES IN CENTRAL NICOTINIC ACETYLCHOLINE CHANNEL KINETICS IN EXCISED PATCHES
Autore:
LESTER RAJ; DANI JA;
Indirizzi:
BAYLOR COLL MED,DIV NEUROSCI,1 BAYLOR PLAZA HOUSTON TX 77030
Titolo Testata:
Neuropharmacology
fascicolo: 1, volume: 33, anno: 1994,
pagine: 27 - 34
SICI:
0028-3908(1994)33:1<27:TCICNA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; D-ASPARTATE RECEPTORS; RAT CENTRAL NEURONS; CHOLINERGIC SYSTEMS; OUT PATCHES; GUINEA-PIG; DESENSITIZATION; CALCIUM; AGONIST; PHOSPHORYLATION;
Keywords:
SYNAPSE; MEDIAL HABENULA; RECEPTOR; RUNDOWN; DESENSITIZATION; LIGAND-GATED; ACETYLCHOLINE; NICOTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.A.J. Lester e J.A. Dani, "TIME-DEPENDENT CHANGES IN CENTRAL NICOTINIC ACETYLCHOLINE CHANNEL KINETICS IN EXCISED PATCHES", Neuropharmacology, 33(1), 1994, pp. 27-34

Abstract

The behavior of nicotinic acetylcholine receptor (nAChR) channels in acutely isolated habenula neurons was examined by rapidly applying nicotinic agonists to outside-out membrane patches. At negative membrane potentials, applications of 100 mu M nicotine routinely produced macroscopic currents due to the opening of a large number of channels. During the continuous application of the agonist, the number of open nAChRchannels decreased exponentially, i.e. receptor desensitization. A progressive loss in the number of channels contributing to the peak current was observed with time following outside-out patch excision, i.e. receptor rundown. In addition to rundown there was a time-dependent increase in the rate of desensitization and a concomitant slowing in therate of recovery from desensitization. The extent of rundown and the changes in desensitization were coupled to the time after patch excision and were not dependent on ligand activation of nicotinic channels.

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Documento generato il 15/07/20 alle ore 08:40:31