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Titolo:
RESPONSE TO SOTALOL PREDICTS THE RESPONSE TO AMIODARONE DURING SERIALDRUG-TESTING IN PATIENTS WITH SUSTAINED VENTRICULAR-TACHYCARDIA AND CORONARY-ARTERY DISEASE
Autore:
MARTINEZRUBIO A; SHENASA M; CHEN X; WICHTER T; BREITHARDT G; BORGGREFE M;
Indirizzi:
UNIV MUNSTER,MED KLIN & POLIKLIN,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,INST RES ARTERIOSCLEROSIS,DEPT CARDIOL & ANGIOL W-4400 MUNSTER GERMANY
Titolo Testata:
The American journal of cardiology
fascicolo: 5, volume: 73, anno: 1994,
pagine: 357 - 360
SICI:
0002-9149(1994)73:5<357:RTSPTR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY TOXICITY; FOLLOW-UP; TERM; FIBRILLATION; THERAPY; ARRHYTHMIAS; EFFICACY; TACHYARRHYTHMIAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Martinezrubio et al., "RESPONSE TO SOTALOL PREDICTS THE RESPONSE TO AMIODARONE DURING SERIALDRUG-TESTING IN PATIENTS WITH SUSTAINED VENTRICULAR-TACHYCARDIA AND CORONARY-ARTERY DISEASE", The American journal of cardiology, 73(5), 1994, pp. 357-360

Abstract

It was analyzed whether the response to sotalol can predict the response to amiodarone as evaluated by programmed ventricular stimulation in 30 patients with coronary artery disease and documented recurrent sustained ventricular tachycardia (VT). Programmed ventricular stimulation was performed using 1 or 2 extrastimuli during sinus rhythm and 4 drive cycle lengths at 2 right ventricular sites. If no ventricular tachyarrhythmia was induced, a third extrastimulus was introduced during a paced cycle length of 500 ms. During the control study, VT (mean cycle length 305 +/- 63 ms) was induced in all patients, and the right ventricular effective refractory period (during S-1-S-1 = 500 ms) was 223 +/- 12 ms. After sotalol, sustained and nonsustained VT were inducible in 22 (73%) and 7 (23%) patients, respectively. One patient did notundergo stimulation on sotalol, because of side effects. After amiodarone, sustained and nonsustained VT were inducible In 23 (71%) and 7 (23%) patients, respectively. The mean cycle length of the induced VT was prolonged after bath drugs by 17% (p < 0.001). The effective refractory period was prolonged by 15% (p < 0.001) after sotalol and by 13% (p < 0.001 compared with baseline study; p = Ns between both drugs) after amiodarone. Thus, concordant results (effective or ineffective drug) between sotalol and amiodarone were found in 26 patients (87%). In conclusion: (1) The effects of sotalol and amiodarone on the cycle length of induced VT and on right ventricular effective refractory periodwere similar; and (2) inability to suppress VT by amiodarone can be predicted from the response to sotalol. Thus, patients who would not respond to amiodarone can be identified, and therefore, do not have to undergo a long hospitalization period for loading dose and subsequent washout of amiodarone before other nonpharmacologic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:42:59