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Titolo:
EFFECTS OF LORAZEPAM ON CARDIAC VAGAL TONE DURING REST AND MENTAL STRESS - ASSESSMENT BY MEANS OF SPECTRAL-ANALYSIS
Autore:
TULEN JHM; MULDER G; PEPPLINKHUIZEN L; INTVELD AJM; VANSTEENIS HG; MOLEMAN P;
Indirizzi:
UNIV HOSP ROTTERDAM DIJKZIGT,DEPT PSYCHIAT,DR MOLEWATERPLEIN 40 ROTTERDAM 3015 NETHERLANDS ERASMUS UNIV ROTTERDAM ROTTERDAM 3015 NETHERLANDS ERASMUS UNIV ROTTERDAM,PATHOPHYSIOL BEHAV SECT ROTTERDAM NETHERLANDS UNIV GRONINGEN,DEPT EXPTL PSYCHOL GRONINGEN NETHERLANDS UNIV HOSP ROTTERDAM DIJKZIGT,DEPT INTERNAL MED ROTTERDAM NETHERLANDS UNIV HOSP DIJKZIGT,DEPT CLIN NEUROPHYSIOL ROTTERDAM NETHERLANDS
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 114, anno: 1994,
pagine: 81 - 89
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE; CARDIOVASCULAR CONTROL; PARASYMPATHETIC CONTROL; BAROREFLEX SENSITIVITY; PSYCHOLOGICAL STRESS; SINUS ARRHYTHMIA; BLOOD-PRESSURE; DIAZEPAM; PLASMA; VARIABILITY;
Keywords:
INTRAVENOUS LORAZEPAM; SPECTRAL ANALYSIS; CARDIAC VAGAL TONE; CARDIOVASCULAR VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.H.M. Tulen et al., "EFFECTS OF LORAZEPAM ON CARDIAC VAGAL TONE DURING REST AND MENTAL STRESS - ASSESSMENT BY MEANS OF SPECTRAL-ANALYSIS", Psychopharmacology, 114(1), 1994, pp. 81-89

Abstract

Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double-blind randomized cross-over study, nine male volunteers participated in two sessions: a placebo andlorazepam session. During these sessions, the subjects repeatedly performed a 10-min version of the Stroop Color Word Test (CWT), with 10 min of rest between the CWTs. Lorazepam was administered before each rest period in increasing doses of 0.0, 0.06, 0.13, 0.25 and 0.5 mg (total cumulative dose: 0.94 mg). During the placebo session the subjects received five placebo injections. For five of the nine subjects the lorazepam session was their first session. Heat rate (HR), blood pressure (BP) and respiration were recorded continuously. Power spectra were calculated per 2.5-min periods for HR, systolic (SBP) and diastolic BP(DBP). Spectral density was assessed for three frequency bands: low (LFB: 0.02-0.06 Hz), mid (MFB: 0.07-0.14 Hz) and high (HFB: 0.15-0.40 Hz). During the consecutive periods of rest, lorazepam induced a dose-dependent decrease in HR, and a dose-dependent increase in LFB, MFB andHFB power of HR, but lorazepam had no effect on BP. The effects were significant after 0.44 mg lorazepam for HR and HFB power, and after 0.94 mg lorazepam for the HR fluctuations in the LFB and MFB. Lorazepam did not influence the cardiovascular responses to the CWT. Our data underline that benzodiazepines can exert a specific influence on parasympathetic activity: lorazepam induced dose-dependent increases in cardiac vagal tone, resulting in decreased HR and increased HR variability,but only during periods of rest. The increase in vagal tone observed after low doses of lorazepam was not related to diminished sympatheticactivity, altered respiration, or increased sedation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:56:06