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Titolo:
DECLINING LYMPHOCYTE COUNTS FOLLOWING CYTOMEGALOVIRUS (CMV) INFECTIONARE ASSOCIATED WITH FATAL CMV DISEASE IN BONE-MARROW TRANSPLANT PATIENTS
Autore:
FRIES BC; KHAIRA D; PEPE MS; TOROKSTORB B;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST,M318 SEATTLE WA 98104 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104
Titolo Testata:
Experimental hematology
fascicolo: 10, volume: 21, anno: 1993,
pagine: 1387 - 1392
SICI:
0301-472X(1993)21:10<1387:DLCFC(>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; CONTROLLED TRIAL; VIRUS INFECTION; T-CELLS; GANCICLOVIR; RECIPIENTS; RECOVERY; REPLICATION; PREVENTION; PNEUMONIA;
Keywords:
CYTOMEGALOVIRUS; LYMPHOCYTOPENIA; BONE MARROW TRANSPLANTATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Fries et al., "DECLINING LYMPHOCYTE COUNTS FOLLOWING CYTOMEGALOVIRUS (CMV) INFECTIONARE ASSOCIATED WITH FATAL CMV DISEASE IN BONE-MARROW TRANSPLANT PATIENTS", Experimental hematology, 21(10), 1993, pp. 1387-1392

Abstract

A previous pilot study conducted on 12 bone marrow transplant recipients suggested that detection of cytomegalovirus (CMV) in lymphocytes was associated with a drop in lymphocyte counts and death due to CMV disease. To test the association between decreasing lymphocytes and CMV-related death, we undertook a retrospective study of 332 CMV-infected patients transplanted between 1987 and 1990. The patients were dividedinto three groups: I = 170 patients who survived their infection and were alive at the time of the study; II = 103 patients who died of causes other than CMV infection; and III = 59 patients who died of CMV disease. Lymphocyte counts were analyzed during a 24-day period, starting 10 days before the day of first positive CMV culture (day 0). Lymphocyte counts were significantly lower in Group III from day 0 through day +14 (p<.001 vs. group I; and p=.002 vs. group II). Multivariate statistical analysis was used to adjust for other differences between thegroups that might influence lymphocyte numbers. Average lymphocyte counts in patients who died of CMV disease decreased by an average of 35% after day 0. The differences in lymphocyte counts remained independent of the effects of acute graft-vs.-host disease (GVHD), time since transplant, transplant type, and high-dose steroid treatment. In summary, these data suggest that in some patients a drop in lymphocyte counts is a consequence of CMV infection associated with fatal CMV disease. Whether this can be attributed to direct infection of lymphocytes, a defective immune response, or some other mechanism remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:40:45