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Titolo:
HIGH ADENOSINE CONTENT IN HUMAN UTERINE SMOOTH-MUSCLE COMPARED WITH STRIATED SKELETAL-MUSCLE
Autore:
RONQUIST G; WEDENBERG K; WALDENSTROM A; ERICSON A; ULMSTEN U;
Indirizzi:
UNIV HOSP UPPSALA,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT OBSTET & GYNAECOL S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN
Titolo Testata:
Clinica chimica acta
fascicolo: 1-2, volume: 223, anno: 1993,
pagine: 93 - 102
SICI:
0009-8981(1993)223:1-2<93:HACIHU>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; GUINEA-PIG MYOMETRIUM; TRANSPORT INHIBITORS; ENERGY-CHARGE; METABOLISM; RECEPTORS; UTERUS; NUCLEOTIDES; NUCLEOSIDES; CELLS;
Keywords:
ADENOSINE; INOSINE; HYPOXANTHINE; XANTHINE; PREGNANCY; UTERINE SMOOTH MUSCLE; SKELETAL STRIATED MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
G. Ronquist et al., "HIGH ADENOSINE CONTENT IN HUMAN UTERINE SMOOTH-MUSCLE COMPARED WITH STRIATED SKELETAL-MUSCLE", Clinica chimica acta, 223(1-2), 1993, pp. 93-102

Abstract

We determined the concentrations of adenosine and some of its catabolic products in biopsy specimens from predetermined loci of human myometrium under different functional conditions to compare uterine muscle with rectus abdominis muscle from the same individuals. In order to achieve a good resolution in the separation of nucleosides and purine bases, a preseparation procedure was developed prior to analysis of these compounds on high performance liquid chromatography. Adenosine occurred in a nearly 70-fold higher concentration in smooth uterine muscle in comparison with striated skeletal muscle. Similarly, myometrial inosine and hypoxanthine were 7- and 2.4-times in excess over the rectus muscle, whereas xanthine was scarcely and rather evenly represented inthe two types of muscles. The uterine content of adenosine and inosine was distinctly higher in pregnant women compared to non-pregnant ones. A regional difference existed for adenosine, with 3.3 times higher concentration in fundus uteri compared to the isthmic part. A reverse pattern was observed for hypoxanthine and inosine, being 2-3 times more frequent in the isthmic part. The orthophosphate concentration was not stoichiometrically related to the adenosine concentration in a simple way, being 2-3 times lower in uterine muscle compared to the skeletal muscle. A significant correlation existed between uterine contents of AMP and adenosine and similarly, significant inverse correlations were apparent between uterine ATP and ADP contents and energy charge onone hand and adenosine content on the other.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:06:05