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Titolo:
C-FES EXPRESSION IN ONTOGENIC DEVELOPMENT AND HEMATOPOIETIC DIFFERENTIATION
Autore:
CARE A; MATTIA G; MONTESORO E; PAROLINI I; RUSSO G; COLOMBO MP; PESCHLE C;
Indirizzi:
IST SUPER SANITA,DEPT HEMATOL ONCOL I-00161 ROME ITALY IST SUPER SANITA,DEPT HEMATOL ONCOL I-00161 ROME ITALY OSPED AVELLINO,DIV OBSTET & GYNECOL I-83100 AVELLINO ITALY IST NAZL STUDIO & CURA TUMORI,DIV EXPTL ONCOL D I-20133 MILAN ITALY THOMAS JEFFERSON UNIV,THOMAS JEFFERSON CANC INST PHILADELPHIA PA 19107
Titolo Testata:
Oncogene
fascicolo: 3, volume: 9, anno: 1994,
pagine: 739 - 747
SICI:
0950-9232(1994)9:3<739:CEIODA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM-FREE CULTURE; TYROSINE PHOSPHORYLATION; PROTO-ONCOGENE; BETA-SUBUNIT; GM-CSF; GROWTH; CDNA; PROGENITORS; RECEPTORS; EMBRYOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Care et al., "C-FES EXPRESSION IN ONTOGENIC DEVELOPMENT AND HEMATOPOIETIC DIFFERENTIATION", Oncogene, 9(3), 1994, pp. 739-747

Abstract

The c-fes protein (NCP92) is a tyrosine-specific protein kinase, capable of both autophosphorylation and phosphorylation of other substrates. We have analysed c-fes RNA expression in human/murine ontogenetic development and in homogenous populations of embryonic and adult human hematopoietic cells. c-fes expression has been observed in rapidly proliferating embryonic-fetal tissues originating from different germinallayers, but not in adult non-hematopoietic tissues. In particular, a spatially and temporally regulated transcription was observed in the central nervous system and in developing cartilage. Expression in hematopoietic cells was evaluated in progenitors purified from embryonic-fetal liver and adult peripheral blood differentiating gradually and specifically along the erythroid or granulomonocytic lineage. In both embryonic and adult hematopoietic cells c-fes was abundantly expressed inundifferentiated progenitors of both lineages, as well as in differentiated granulomonocytic precursors, but not in erythroblasts. This expression pattern correlates with that of GM-CSF and in part IL-3 receptors (Testa et al., 1993 and our unpublished results). Altogether, these results suggest a possible role for c-fes in signal transduction, inboth embryonic non-hematopoietic tissues and embryonic/ adult hematopoietic cells, following interaction of growth factors with their tyrosine-kinase negative receptors (i.e., GM-CSF and IL-3 receptors in adult hematopoietic cells and other hypothetical growth factor(s) receptors during embryonic development).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 09:50:28