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Titolo:
SUBSTITUTED PURINES ELICIT DIFFERENTIAL CYTOKINETIC, MOLECULAR AND PHENOTYPIC EFFECTS IN HL-60 CELLS
Autore:
DAVIDOFF AN; MENDELOW BV;
Indirizzi:
UNIV WITWATERSRAND,SCH MED,DEPT HAEMATOL,YORK RD JOHANNESBURG 2193 SOUTH AFRICA S AFRICAN INST MED RES,SCH PATHOL,DEPT HAEMATOL JOHANNESBURG SOUTH AFRICA
Titolo Testata:
Experimental hematology
fascicolo: 3, volume: 21, anno: 1993,
pagine: 456 - 460
SICI:
0301-472X(1993)21:3<456:SPEDCM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYC MESSENGER-RNA; KINASE-ACTIVITY; C-FOS; DEGRADATION; EXPRESSION; INDUCTION; OOCYTE; ARREST; DEATH;
Keywords:
HL-60; PUROMYCIN; PUROMYCIN AMINONUCLEOSIDE; 6-DIMETHYLAMINOPURINE; C-MYC MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.N. Davidoff e B.V. Mendelow, "SUBSTITUTED PURINES ELICIT DIFFERENTIAL CYTOKINETIC, MOLECULAR AND PHENOTYPIC EFFECTS IN HL-60 CELLS", Experimental hematology, 21(3), 1993, pp. 456-460

Abstract

This study investigated and compared the cytokinetic, phenotypic and molecular effects elicited in HL-60 human leukemic cells by low doses (0.6 mu M) of 3 closely related, substituted purines, puromycin (PM), puromycin aminonucleoside (PAN) and 6-dimethylaminopurine (6-DMAP). PM, but not 6-DMAP or PAN, inhibited [C-14]leucine incorporation, induced a time-related cytotoxic effect, a G(2)- arrest, a metaphase-mitotic-arrest, apoptosis and c-myc mRNA superinduction. PAN and 6-DMAP exerted no detectable morphological or cytokinetic effects, although exposure to these drugs resulted in downregulation of c-myc mRNA levels. We suggest that the specific effects exerted by PM relate to the generation of nascent peptidyl-PM complexes by PM, but not by 6-DMAP or PAN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:25:38