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Titolo:
D-AMPHETAMINE-LIKE STIMULUS PROPERTIES ARE PRODUCED BY MORPHINE INJECTIONS INTO THE VENTRAL TEGMENTAL AREA BUT NOT INTO THE NUCLEUS-ACCUMBENS
Autore:
DRUHAN JP; DESCHAMPS SE; STEWART J;
Indirizzi:
CONCORDIA UNIV,CTR STUDIES BEHAV NEUROBIOL,DEPT PSYCHOL,1455 MAISONNEUVE BLVD W MONTREAL H3A 1M8 PQ CANADA CONCORDIA UNIV,CTR STUDIES BEHAV NEUROBIOL,DEPT PSYCHOL MONTREAL H3A 1M8 PQ CANADA
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 59, anno: 1993,
pagine: 41 - 51
SICI:
0166-4328(1993)59:1-2<41:DSPAPB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; SELF-ADMINISTRATION BEHAVIOR; MESOLIMBIC DOPAMINE SYSTEM; INDUCED LOCOMOTOR-ACTIVITY; INTRA-ACCUMBENS; MICRO-INJECTION; RATS; COCAINE; HEROIN; MEDIATION;
Keywords:
OPIOID; PSYCHOMOTOR STIMULANT; DRUG DISCRIMINATION; LOCOMOTOR ACTIVITY; MESOLIMBIC DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Druhan et al., "D-AMPHETAMINE-LIKE STIMULUS PROPERTIES ARE PRODUCED BY MORPHINE INJECTIONS INTO THE VENTRAL TEGMENTAL AREA BUT NOT INTO THE NUCLEUS-ACCUMBENS", Behavioural brain research, 59(1-2), 1993, pp. 41-51

Abstract

We investigated whether injections of morphine into the ventral tegmental area (VTA) or the nucleus accumbens (NAS) could produce amphetamine-like stimulus properties and locomotor stimulant effects. Rats weretrained to discriminate 1.0 mg/kg D-amphetamine from saline using both VI-30 and FR-16 reinforcement schedules and they were then tested following bilateral injections of morphine sulfate (2.5, 5.0 and 10.0 mug/side) either into the VTA or the NAS. Intra-VTA injections of morphine produced significant increases in amphetamine-lever responding that were comparable to increases observed following intra-NAS D-amphetamine (2.5, 5.0 and 10.0 mu g/side). Such increases were not observed, however, following intra-NAS injections of morphine. Tests for the effects of intracerebral morphine and D-amphetamine on locomotor activity produced a similar pattern of results. Locomotor activity was increased following intra-VTA morphine and intra-NAS D-amphetamine injections,but not after intra-NAS morphine injections. Together, these findingsindicate that activation of opioid receptors within the VTA, but not the NAS, can produce a behavioral state which mimics to some degree the state produced by systemic and intra-NAS injections of D-amphetamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:07:38