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Titolo:
DEMENTIA WITH LEWY BODIES - RELIABILITY AND VALIDITY OF CLINICAL AND PATHOLOGICAL CRITERIA
Autore:
MEGA MS; MASTERMAN DL; BENSON DF; VINTERS HV; TOMIYASU U; CRAIG AH; FOTI DJ; KAUFER D; SCHARRE DW; FAIRBANKS L; CUMMINGS JL;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,710 WESTWOOD PLAZA LOS ANGELES CA 90025 W LOS ANGELES VET AFFAIRS MED CTR,SECT NEUROPATHOL,DEPT LAB SERV LOS ANGELES CA 90073 UNIV PITTSBURGH,DEPT NEUROL PITTSBURGH PA 15260 OHIO STATE UNIV,DEPT NEUROL COLUMBUS OH 43210
Titolo Testata:
Neurology
fascicolo: 6, volume: 47, anno: 1996,
pagine: 1403 - 1409
SICI:
0028-3878(1996)47:6<1403:DWLB-R>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE CERAD; SUPRANUCLEAR GAZE PALSY; BODY DISEASE; SENILE DEMENTIA; PARKINSONS-DISEASE; FEATURES; VARIANT; PROGRESSION; CONSORTIUM; IMPAIRMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Mega et al., "DEMENTIA WITH LEWY BODIES - RELIABILITY AND VALIDITY OF CLINICAL AND PATHOLOGICAL CRITERIA", Neurology, 47(6), 1996, pp. 1403-1409

Abstract

Clinical criteria for dementia with Lewy bodies (DLB) have been proposed, but their formulation, reliability, and validity require further study. Pathologic criteria for DLB are also undergoing evolution. Two studies were conducted with the goal of identifying the components of these evolving criteria that may benefit from further refinement; one study evaluated the components of the clinical criteria and another study operationalized the pathologic criteria for DLB. Twenty-four patients with a premorbid diagnosis of probable or possible Alzheimer's disease (AD) (n = 18), Parkinson's disease (PD) (n = 5), or progressive supranuclear palsy (PSP) (n = 1) were studied, Inter-rater reliability and validity of the clinical criteria were determined by a retrospective chart review, done by five neurologists, and a blinded pathologic evaluation. The Consortium on dementia with Lewy bodies (CDLB) pathologic criteria were operationalized to compare past criteria and test thevalidity of the evolving clinical criteria on the dementia patients. Three or more cortical fields (at 250x magnification) with many (four or more) Lewy bodies (LBs) on ubiquitin immunoreactive sections were required to meet the CDLB neocortical score of >6. Fifteen of the AD patients had at least one LB in a cortical section, four had many LBs, while three had no LBs; all patients with movement disorder had at least one LB in a cortical section. The sensitivity/specificity ratio of the CDLB probable DLB clinical criteria based upon many LBs being present was 75%/79%. Reformulated clinical criteria that require the presence of extrapyramidal signs significantly predicted those patients withmany LBs versus those with few or no LBs (chi(2) = 5.48, p = 0.02) and increased clinical specificity to 100%. This preliminary study identifies components of the evolving clinical and pathologic criteria for DLB that require further refinement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:27:59