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Titolo:
THE INFLUENZA-VIRUS VARIANT A FM/1/47-MA POSSESSES SINGLE AMINO-ACID REPLACEMENTS IN THE HEMAGGLUTININ, CONTROLLING VIRULENCE, AND IN THE MATRIX PROTEIN, CONTROLLING VIRULENCE AS WELL AS GROWTH/
Autore:
SMEENK CA; BROWN EG;
Indirizzi:
UNIV OTTAWA,FAC MED,DEPT MICROBIOL & IMMUNOL,451 SMYTH RD OTTAWA K1H 8M5 ON CANADA UNIV OTTAWA,FAC MED,DEPT MICROBIOL & IMMUNOL OTTAWA K1H 8M5 ON CANADA
Titolo Testata:
Journal of virology
fascicolo: 1, volume: 68, anno: 1994,
pagine: 530 - 534
SICI:
0022-538X(1994)68:1<530:TIVAFP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
A VIRUS; MONOCLONAL-ANTIBODIES; SEQUENCE CHANGES; M1 PROTEIN; H2N2; IDENTIFICATION; NUCLEOPROTEIN; GLYCOPROTEIN; TRANSPORT; SEGMENTS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Smeenk e E.G. Brown, "THE INFLUENZA-VIRUS VARIANT A FM/1/47-MA POSSESSES SINGLE AMINO-ACID REPLACEMENTS IN THE HEMAGGLUTININ, CONTROLLING VIRULENCE, AND IN THE MATRIX PROTEIN, CONTROLLING VIRULENCE AS WELL AS GROWTH/", Journal of virology, 68(1), 1994, pp. 530-534

Abstract

Genetic analysis of mouse-adapted influenza virus variant A/FM/1/47 (FM) MA has previously identified four genome segments, 4, 5, 7, and 8,that are statistically associated with virulence. On sequencing thesegenome segments, we found single amino acid replacements at amino acid 47 of the HA2 subunit of the hemagglutinin and at amino acid 139 of the matrix protein. Mutation was not detected in segments 5 and 8, obviating a role for these genes in FM-MA virulence. FM-MA replicates to higher titer than FM in MDCK cells and in mouse lung. FM X FM-MA reassortants were used to show that the M1 gene controlled replication in MDCK cells as well as in mouse lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:56:54