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Titolo:
HIGH-INCIDENCE OF ANAL CANCER AMONG AIDS PATIENTS
Autore:
MELBYE M; COTE TR; KESSLER L; GAIL M; BIGGAR RJ; LEMP G; WEST D; SINGLETON J; YOUNG J; KERNDT P; DEAPEN D; GINZBERG M; ANTONCULVER H; LIEB S; HOPKINS R; WILLIAMS B; LIFF J; MORGAN D; PARKIN W;
Indirizzi:
NCI,DIV CANC ETIOL,VIRAL EPIDEMIOL BRANCH,EPN-434,6130 EXECUT BLVD ROCKVILLE MD 20852 NCI,DIV CANC ETIOL,VIRAL EPIDEMIOL BRANCH ROCKVILLE MD 20852 STATE SERUM INST,DANISH EPIDEMIOL SCI CTR COPENHAGEN DENMARK NCI,DIV CANC PREVENT & CONTROL,APPL RES BRANCH ROCKVILLE MD 20852 NCI,DIV CANC ETIOL,BIOSTAT BRANCH ROCKVILLE MD 20852
Titolo Testata:
Lancet
fascicolo: 8898, volume: 343, anno: 1994,
pagine: 636 - 639
SICI:
0140-6736(1994)343:8898<636:HOACAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IV HIV DISEASE; INTRAEPITHELIAL NEOPLASIA; PAPILLOMAVIRUS INFECTION; HUMAN IMMUNODEFICIENCY; HOMOSEXUAL MEN; MARITAL-STATUS; CARCINOMA; ASSOCIATION; PARALLEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Melbye et al., "HIGH-INCIDENCE OF ANAL CANCER AMONG AIDS PATIENTS", Lancet, 343(8898), 1994, pp. 636-639

Abstract

Until now, the only cancers that have been strongly associated with AIDS are Kaposi's sarcoma and non-Hodgkin lymphoma. We used a linkage between AIDS (50 050 reports) and cancer (859 398 reports) registries in seven health departments in the USA to investigate the association between HIV infection and epidermoid anal cancer. We compared the numbers of observed cases and expected cases, calculated from general population rates with adjustment for age, sex, and race. The relative risk of anal cancer at and after AIDS diagnosis was 84.1 (95% CI 46.4-152) among homosexual patients (11 cases) and 37.7 (9.4-151) among non-homosexual patients (2 cases). The relative risk of anal cancer up to 5 years before the AIDS diagnosis (23 cases) was also increased; it was 13.9 (6.6-29.2) in the period 2-5 years before AIDS and 27.4 (15.9-47.2)during the 2 years before AIDS diagnosis (p for trend = 0.004). Amonghomosexual men, the relative risk of anal cancer was inversely related to age at AIDS onset (p for trend < 0.001). Excess risks were found in all geographical areas. This study establishes a strikingly increased risk of anal cancer among people with AIDS, These data are consistent with a previously hypothesised association between HIV-induced immunodeficiency and anal cancer development, but because homosexual men were at increased risk of anal cancer even before the AIDS epidemic, wecannot say how much of the increased risk is attributable to HIV infection. Nevertheless, clinicians should be aware that AIDS patients have an increased risk of anal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:41:05