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Titolo:
CLASP - A RANDOMIZED TRIAL OF LOW-DOSE ASPIRIN FOR THE PREVENTION ANDTREATMENT OF PREECLAMPSIA AMONG 9364 PREGNANT-WOMEN
Autore:
BEROYZ G; CASALE R; FARREIROS A; PALERMO M; MARGULIES M; VOTO L; FABREGUES G; RAMALINGAM R; DAVIES T; BRYCE R; BOYD W; CARMODY F; KING J; VACCA A; FAY R; WALTERS W; ANTONAS B; BENNETT P; BROOM T; CROWTHER C; DERHAM R; GEORGE K; HAGUE W; HASENHOHR G; HEYSEN D; KORNMAN L; OLOUGHLIN S; MORRIS D; PRIDMORE B; ROBINSON J; SVIGOS D; SWEET R; BEALE M; BENNETT M; BOSCH E; FISHER C; HORRAUTZ S; SYMINGTON I; SZIRT A; FORBES K; FREEMAN A; POPPER E; WILSON J; PERMEZEL M; BOWDITCH J; REYNOLDS G; MOULINASSE R; BIETLOT Y; KIRKPATRICK C; COULON R; DELVOYE P; DEMATOS CF; SIMONINI S; LEJEUNE B; NEERDAELS C; ALEXANDER S; GOESSENS L; HANSSENS M; SPITZ B; VANASSCHE A; WECKHUYSEN R; PARBOOSINGH J; HARMAN C; REY E; BURROWS R; BELCHER J; GARNER P; SYLVAIN J; NIMROD C; THOMAS B; DEININGER F; LAO T; LI C; FRIEDMAN S; BORNSTEIN J; SHALIT A; MATZKEL A; POMERANZ M; GELSNER M; MANKUTA D; WIZNITZER A; LEVINE S; ADEEB N; CHANDRAN R; NASRI N; SHARIFF J; ANSELL D; LAKE Y; GOROCHOVA L; MERIAKRI V; ROMANUGA N; DOTZ I; SHEUV B; VIKHLYAEVA E; ANDREEV K; GOLUBEVA L; GORODCOV V; ADELANTADO J; SANTONJA J; HOLMBERG H; BUCHHAVE P; LEANDERSSON U; LILJESTRAND J; RYDHSTROEM H; SWEDIN G; BJORKLUND A; GENNSER G; SANDEN MC; DAHLGREN S; HAMMARBACK S; SMEDS A; SIDENVALL M; ENEROTH E; SZABOLCS A; DANIELSSON I; LINDQVIST P; HOGSTEDT S; WALLENBURG H; BREMER H; BRIET J; DEBIEMEYERINK A; DONKERS B; LAMPING P; SCHIERBEEK J; VANDERLEEUWHARMSEN L; THE H; VANBODEGOM F; VANEGMONDLINDEN A; FLU P; KUIJKEN J; MORREL B; STRAUB M; VIERHOUT M; KEIRSE M; VANROOSMALEN J; HOHNER C; HUTTEN J; BENNEN J; ROEX A; WIJFFELS T; OOSTERHOFF H; OTTEN J; VANDERKLEI T; RAMONDT J; VANDERMOER P; DEGRAAFF J; SIJSMA E; DEGREVE O; SMIT D; SMULDERS P; NIJHUIS J; ZONDERVAN H; LIND J; SCHOOT B; MONKHORST M; STUT J; VANDAM L; VANOTTERLO L; VLAANDEREN W; EGGENS J; SANTEMA J; VERHOEFF A; HAMID S; JOHN I; KHAN G; SHAH S; SHEIKH E; SINHA C; ABRAMOVICH D; CAMPBELL D; FISHER P; GALL S; HALL M; JANDIAL V; PARKIN D; SMITH N; SUTHERLAND H; SWAPP G; TEMPLETON A; TERRY P; KALAM A; MAGEE S; MARTIN D; SPEARING G; ALDERMAN B; MURRAY A; SUTHERST J; HYATT D; SAUNDERS P; BURGESS S; COCHRANE G; WHITE A; ARMSTRONG M; MCNICHOL E; OSBOURNE G; PRICE J; CRICHTON J; EVANS D; ANDERSON R; HULL M; JAMES D; NIVEN P; STIRRAT G; WARDLE P; GARDNER P; PADGETT L; ALAILY A; NASH G; GINZ B; SMITH M; RICHARDS C; ARMAR A; ARMSTRONG N; MANNING E; PERSAD K; COLLINGWOOD M; COLLINS R; CROWTHER J; FARRELL B; HAFNER B; HANDOLL H; HEINEMAN J; KNIGHT S; MEAD G; RADLEY A; SPENCE S; REID W; TREHARNE I; HEASLEY R; LOWRY D; MYLES T; WALLACE R; GEALS M; GORDON G; TRAIN T; HUTCHON D; MACDONALD J; STOREY R; ANDERSON G; WORTH R; ERIAN J; MCQUEEN J; TATFORD E; TERRY M; NEALE R; HOWAT R; KENNEDY J; MACNAUGHTON M; MCEWAN H; WALKER J; HUTCHESON R; KEMP V; READ M; SIMMS M; SWINGLER G; HUSEMEYER R; CHAPMAN M; MAXWELL D; ELDER M; FUSI L; HAWKINS D; NICOLINI U; WINSTON R; BURTON E; FAIRBANK J; SIMMONS S; SPING J; TRICKEY N; EVANS D; GILLARD M; HUDSON C; SETCHELL M; WATHEN N; CANTY S; WHITELEY P; CAMPBELL J; FEENEY J; HAY D; IMRIE A; PALMER A; PURDIE D; SPECK E; TYRRELL S; MCLEAN J; BROWN V; DUNCAN S; JOHNSON D; MILLAR D; BUCKLEY D; CHARNOCK M; DOVE P; ELLIS J; GILLMER M; MCVITTIE J; MANNION V; REDMAN CWG; SELLERS S; TURNBULL A; NEWMAN M; CAMPBELL S; CARDOSO L; GIBB D; HARRINGTON K; PARSONS J; NICOLAIDES K; STUDD J; DIXON R; GIE C; PICKLES C; SEAR R; GRAHAM R; KIRWAN P; SMITH G; ANWAR M; ALAZZAWI F; DAVIDSON A; DECHAZEL R; DRIFE J; GILL F; LANG G; MACAFEE J; MACVICAR J; NAFTALIN N; NEUBERG R; TAYLOR D; LEAVER E; TIMOTHY I; CRICHTON J; BREESON A; LAMB M; VELACOTT I; VERNER V; HORWELL D; LOBB M; SELIGMAN S; SCOTT A; HALL S; MACKENZIE W; SMITH E; VETHANAVAGAN S; VERZIN J; WEIR P; WHITE R; CLARK H; FAWDRY R; LYNCH C; MCCUNE G; BOWENSIMPKINS P; CALVERT J; EMERY S; JACKSON W; STOKES I; WARD A; BROWNING A; COX C; LITTLE D; STIBBE H; MCINTOSH A; SNODGRASS C; WAGSTAFF T; HOWIE P; TAYLOR D; BIBBY J; DAVIES W; ELLIOTT B; SHAXTED E; MCGARRY J; DAW E; BAKER K; CLUBB A; GOUGH J; GRANT M; MENON V; OBHARI M; OBRIEN P; REDMAN C; BROWN R; RYALL A; WALTON S; BAKER J; BRUCE J; LIU D; JOHNSON I; TYACK A; COWIE D; NYSENBAUM A; BAMFORD P; GARRIOCH D; HILL J; GRANT A; FELTON D; HACKMAN B; FALCONER A; FREEMAN F; GREENE K; JACKSON J; HUNTER G; GRATTON D; MAULIK T; YOUSSEF H; BANWELL G; HARTWELL R; WILSON P; BOND A; FORBESSMITH P; BARRON L; DAVISON J; DUNLOP W; LIND T; TACCHI D; BALFOUR R; MUTCH L; COLTART T; DESWIET M; EDMONDS D; LOEFFLER F; MALVERN J; MORRIS D; OSBOURNE J; RODECK C; SIMS C; SPENCER J; BONE C; MACDONALD A; DREW N; BALLARD R; THONET R; WORTH R; HANNA L; MORCOS S; HOLT E; COOPER J; CALLEN P; FOZZARD C; GRUNDY M; STANLEY S; DANIEL D; GOLDING R; WIENER J; BUCKINGHAM M; HEARD M; LETCHWORTH A; BOOMLA K; CLARK A; GRUDZINSKAS J; HARTGILL J; ORAM D; ROBSON J; SAVAGE W; BLUNT V; LANE J; OWEN A; REDFORD D; BEARD R; BOSTOCK J; MEASDAY B; MELVILLE H; DORNAN J; TRAUB A; UTIDJIAN M; AULD A; KRASZEWSKI A; MACK D; MCDOUGALL N; MOWAT J; DOCHERTY P; MCKENNA D; SMEDLEY G; WILDE J; SMITH R; WATNEY P; MCDONNELL J; TROMAMS P; CALDER A; GLASIER A; GREER I; JOHNSTONE F; LISTON W; LIVINGSTONE J; NEILSON J; SMITH S; WEST C; BULLOUGH C; JONES A; MACKAY G; COOPER K; RUOSS C; JAMES D; JOYCE D; MCCOY D; MCLEOD F; SAVAGE P; SMITH P; TURNER G; KANE L; ROSENBERG D; SHANNON R; BROMHAM D; BUCHAN P; CROMPTON A;
Indirizzi:
RADCLIFFE INFIRM,CLASP COORDINATING CTR,HARKNESS BLDG OXFORD OX2 6HE ENGLAND HOSP NACL ALEJANDROS POSADAS BUENOS AIRES ARGENTINA JUAN A FERNANDEZ HOSP BUENOS AIRES ARGENTINA POLICLIN BANCARIA BUENOS AIRES ARGENTINA BROKEN HILL BASE HOSP BROKEN HILL NSW AUSTRALIA BUNDABERG HOSP BUNDABERG QLD AUSTRALIA FLINDERS MED CTR BEDFORD PK SA AUSTRALIA MACKAY BASE HOSP MACKAY QLD AUSTRALIA MATER MOTHERS HOSP BRISBANE QLD AUSTRALIA NEPEAN HOSP PENRITH NSW AUSTRALIA NEWCASTLE MATER HOSP WARATAH AUSTRALIA QUEEN VICTORIA HOSP ADELAIDE SA AUSTRALIA ROYAL HOSP WOMEN PADDINGTON AUSTRALIA ROYAL HOSP WOMEN HERSTON QLD AUSTRALIA ROYAL WOMENS HOSP PARKVILLE VIC AUSTRALIA ST GEORGE HOSP MILDURA VIC AUSTRALIA CLIN NOTRE DAME TOURNAI BELGIUM CLIN ST PIERRE WAVRE BELGIUM HOP ERASME BRUSSELS BELGIUM HOP MADELEINE ATH BELGIUM HOP ST PIERRE & ERASME BRUSSELS BELGIUM INST MEDICOCHIRURG TOURNAI BELGIUM MATERN IXLLES BRUSSELS BELGIUM UNIV ZIEKENHUIS GASTHUISBERG LEUVEN HOSP GRP,1 LOUVAIN BELGIUM FOOTHILLS PROV GEN HOSP CALGARY AB CANADA HLTH SCI CTR WINNIPEG MB CANADA HOP ST JUSTINE MONTREAL PQ CANADA MCMASTER UNIV HAMILTON ON CANADA OTTAWA CIVIC HOSP OTTAWA ON CANADA OTTAWA GEN HOSP OTTAWA ON CANADA WOMENS COLL HOSP TORONTO ON CANADA UNIV MUNICH,FRAUENKLIN MUNICH GERMANY PRINCE WALES HOSP SHA TIN HONG KONG BEILINSON MED CTR PETAH TIQWA ISRAEL CARMEL HOSP HAIFA ISRAEL HILLEL JAFFE HOSP HADERA ISRAEL KAPLAN HOSP REHOVOT ISRAEL MEIR HOSP KEFAR SAVA ISRAEL SOROKA MED CTR BEER SHEVA ISRAEL WOLFSON MED CTR HOLON ISRAEL MATERN HOSP KUALA LUMPUR MALAYSIA MIDDLEMORE HOSP AUCKLAND NEW ZEALAND MATERN HOSP IRKUTSK RUSSIA CHELYABINSK MED INST CHELYABINSK RUSSIA RUSSIAN SCI CTR MOSCOW RUSSIA SCI RES CTR IVANOVO RUSSIA HOSP SANTA CRUZ & SAN PABLO BARCELONA SPAIN UNIV VALENCIA VALENCIA SPAIN CENT HOSP KALMAR SWEDEN CENT HOSP KARLSKRONA KARLSKRONA SWEDEN CITY HOSP OSTERSUND SWEDEN DANDERYD HOSP DANDERYD SWEDEN ESKILSTUNA CTY HOSP STOCKHOLM SWEDEN HUDIKSVALLS SJUKHUS HUDIKSVALL SWEDEN SODER SJUKHUSET STOCKHOLM SWEDEN SODERTALJE SJUKHUS SODERTALJE SWEDEN SUNDSVALLS SJUKHUS KK SUNDSVALL SWEDEN VASTERAS HOSP VASTERAS SWEDEN DIJKZIGT ACAD HOSP ROTTERDAM NETHERLANDS GEERTRUIDEN ZIEKENHUIS DEVENTER NETHERLANDS GEMINI ZIEKENHUIS DEN HELDER NETHERLANDS HOFPOORT ZIEKENHUIS WOERDEN NETHERLANDS IKAZIA ZIEKENHUIS ROTTERDAM NETHERLANDS LEIDEN UNIV HOSP LEIDEN NETHERLANDS LIEVENSBERG ZIEKENHUIS BERGEN OP ZOO NETHERLANDS MED CTR ALKMAAR ALKMAAR NETHERLANDS PASTEUR ZIEKENHUIS OOSTERHOUT NETHERLANDS RODE KRUIS ZIEKENHUIS HEEMSKERK NETHERLANDS ST CLARA HOSP ROTTERDAM NETHERLANDS ST ELIZABETH HOSP TILBURG NETHERLANDS ST JANSDAL ZIEKENHUIS HARDERWIJK NETHERLANDS TWENTEBORG ZIEKENHUIS ALMELO NETHERLANDS UNIV HOSP NIJMEGEN NIJMEGEN NETHERLANDS UNIV AMSTERDAM AMSTERDAM NETHERLANDS WESTEINDE ZIEKENHUIS THE HAGUE NETHERLANDS ZIEKENHUIS CTR APELDOORN NETHERLANDS ZIEKENHUZEN RYNSTAETE & VELP ARNHEM NETHERLANDS ZUIDER ZIEKENHUIS ROTTERDAM NETHERLANDS CORNICHE HOSP ABU DHABI U ARAB EMIRATES ABERDEEN MATERN HOSP ABERDEEN ABERDEEN SCOTLAND ALTNAGELVIN HOSP LONDONDERRY LONDONDERRY NORTH IRELAND ARROWE PK HOSP WIRRAL MERSEYSIDE ENGLAND ASHFORD HOSP ASHFORD KENT ENGLAND BARKING HOSP BARKING ENGLAND BELFAST CITY HOSP BELFAST ANTRIM NORTH IRELAND BELLSHILL MATERN HOSP BELLSHILL SCOTLAND BORDERS GEN HOSP MELROSE SCOTLAND BRISTOL ST MICHAELS HOSP BRISTOL AVON ENGLAND BRONGLAIS GEN HOSP ABERYSTWYTH DYFED WALES BUCHANAN HOSP ST LEONARDS ON SEA ENGLAND BURTON DIST HOSP CTR BURTON TRENT STAFFS ENGLAND CAERPHILLY DIST MINERS HOSP CAERPHILLY M GLAM WALES CENT MIDDLESEX HOSP LONDON ENGLAND RADCLIFFE INFIRM,CLIN TRIAL SERV UNIV OXFORD OXON ENGLAND CITY MATERN HOSP CARLISLE CUMBRIA ENGLAND COLCHESTER MATERN HOSP COLCHESTER ESSEX ENGLAND CRAIGAVON AREA HOSP CRAIGAVON NORTH IRELAND CRESSWELL MATERN HOSP DUMFRIES DUMFRIES SCOTLAND DARLINGTON MEM HOSP DARLINGTON DURHAM ENGLAND DOWNPATRICK MATERN HOSP DOWNPATRICK DOWN NORTH IRELAND
Titolo Testata:
Lancet
fascicolo: 8898, volume: 343, anno: 1994,
pagine: 619 - 629
SICI:
0140-6736(1994)343:8898<619:C-ARTO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASSIFYING PERINATAL DEATH; INDUCED HYPERTENSION; FETAL; PREECLAMPSIA; RISK; PROSTACYCLIN; PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G. Beroyz et al., "CLASP - A RANDOMIZED TRIAL OF LOW-DOSE ASPIRIN FOR THE PREVENTION ANDTREATMENT OF PREECLAMPSIA AMONG 9364 PREGNANT-WOMEN", Lancet, 343(8898), 1994, pp. 619-629

Abstract

Pre-eclampsia is a common and serious complication of pregnancy that affects both mother and child. Review of previous small trials of antiplatelet therapy, particularly low-dose aspirin, suggested reductions of about three-quarters in the incidence of pre-eclampsia and some avoidance of intrauterine growth retardation (IUGR), but larger trials have not confirmed these results. In our multicentre study 9364 women were randomly assigned 60 mg aspirin daily or matching placebo. 74% wereentered for prophylaxis of pre-eclampsia, 12% for prophylaxis of IUGR, 12% for treatment of pre-eclampsia, and 3% for treatment of IUGR. Overall, the use of aspirin was associated with a reduction of only 12% in the incidence of proteinuric pre-eclampsia, which was not significant. Nor was there any significant effect on the incidence of IUGR or of stillbirth and neonatal death. Aspirin did, however, significantly reduce the likelihood of preterm delivery (19.7% aspirin vs 22.2% control; absolute reduction of 2.5 [SD 0.9] per 100 women treated; 2p = 0.003). There was a significant trend (p = 0.004) towards progressively greater reductions in proteinuric preeclampsia the more preterm the delivery. Aspirin was not associated with a significant increase in placental haemorrhages or in bleeding during preparation for epidural anaesthesia, but there was a slight increase in use of blood transfusion after delivery. Low-dose aspirin was generally safe for the fetus and newborn infant, with no evidence of an increased likelihood of bleeding. Our findings do not support routine prophylactic or therapeutic administration of antiplatelet therapy in pregnancy to all women at increased risk of pre-eclampsia or IUGR. Low-dose aspirin may be justified inwomen judged to be especially liable to early-onset pre-eclampsia severe enough to need very preterm delivery. In such women it seems appropriate to start low-dose aspirin prophylactically early in the second trimester.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:01:32