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Titolo:
INTERACTION OF HEPATITIS-B VIRUS-X PROTEIN WITH A SERINE-PROTEASE, TRYPTASE TL(2) AS AN INHIBITOR
Autore:
TAKADA S; KIDO H; FUKUTOMI A; MORI T; KOIKE K;
Indirizzi:
JFCR,INST CANC,DEPT GENE RES,TOSHIMA KU,1-37-1 KAMI IKEBUKURO TOKYO TOKYO 170 JAPAN JFCR,INST CANC,DEPT GENE RES,TOSHIMA KU TOKYO TOKYO 170 JAPAN UNIV TOKUSHIMA,INST ENZYME RES,DIV ENZYME CHEM TOKUSHIMA 770 JAPAN
Titolo Testata:
Oncogene
fascicolo: 2, volume: 9, anno: 1994,
pagine: 341 - 348
SICI:
0950-9232(1994)9:2<341:IOHVPW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUKARYOTIC TRANSCRIPTIONAL ACTIVATORS; ERYTHROID-POTENTIATING ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; PROMOTER TRANS-ACTIVATION; LONG TERMINAL REPEAT; RAT MAST-CELLS; NUCLEOTIDE-SEQUENCE; GENE-PRODUCT; TRANSACTIVATION FUNCTION; HUMAN LYMPHOCYTES-T4+;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
S. Takada et al., "INTERACTION OF HEPATITIS-B VIRUS-X PROTEIN WITH A SERINE-PROTEASE, TRYPTASE TL(2) AS AN INHIBITOR", Oncogene, 9(2), 1994, pp. 341-348

Abstract

X protein of hepatitis B virus (HBV) transactivates transcription of various viral and cellular genes. It has been suggested that X proteinplays a major role in hepatocarcinogenesis by HBV. The protein possesses amino acid sequence homology to the functionally essential domain of Kunitz-type serine protease inhibitors. This Kunitz domain-like sequence in X protein is indispensable for the transactivation function. To clarify whether X protein has a serine protease inhibitor activity,a search was made for serine proteases which interact with, but not degrade X protein. Tryptase TL,, one of serine proteases in hepatic cells, was found to directly interact with X protein without degradation. Moreover, the activities of tryptase TL, and an analogous protease were substantially inhibited by X protein. These results suggest that transactivation function of X protein is exerted by modulation of the hepatic serine protease activity, giving rise to quantitative or qualitative change of cellular transcription factor(s) through protection from proteolytic degradation and/or suppression of processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:40:58