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Titolo:
RELATIONSHIP BETWEEN POSTPRANDIAL RELEASE OF CCK AND PP IN HEALTH ANDIN CHRONIC-PANCREATITIS
Autore:
GLASBRENNER B; DOMINGUEZMUNOZ JE; NELSON DK; RIEPL RL; BUCHLER M; MALFERTHEINER P;
Indirizzi:
UNIV BONN,MED KLIN,SIGMUND FREUD STR 25 D-53127 BONN GERMANY UNIV ULM,DEPT INTERNAL MED W-7900 ULM GERMANY UNIV ULM,DEPT GEN SURG ULM GERMANY UNIV MUNICH,MED KLIN INNENSTADT W-8000 MUNICH GERMANY
Titolo Testata:
Regulatory peptides
fascicolo: 1, volume: 50, anno: 1994,
pagine: 45 - 52
SICI:
0167-0115(1994)50:1<45:RBPROC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA CHOLECYSTOKININ; POLYPEPTIDE RELEASE; FEEDBACK-REGULATION; INTESTINAL PHASE; ENZYME SECRETION; HUMANS; INSUFFICIENCY; SUPPRESSION; TRYPSIN;
Keywords:
CHOLECYSTOKININ; PANCREATIC POLYPEPTIDE; CHRONIC PANCREATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
B. Glasbrenner et al., "RELATIONSHIP BETWEEN POSTPRANDIAL RELEASE OF CCK AND PP IN HEALTH ANDIN CHRONIC-PANCREATITIS", Regulatory peptides, 50(1), 1994, pp. 45-52

Abstract

The aim of this study was to investigate the relationship between postprandial release of cholecystokinin (CCK) and pancreatic polypeptide (PP) in healthy subjects and patients with chronic pancreatitis (CP). 14 patients with CP and 14 age-matched healthy subjects were studied. Diagnosis of CP was confirmed by standardized imaging modalities (ERCPand CT). Exocrine pancreatic function was assessed in all 28 subjectsusing the pancreolauryl serum test (PLT). An oral test meal was administered to stimulate endogenous hormone release. Plasma samples were taken before and at several time points after the test meal. CCK and PPplasma levels were measured by specific radioimmunoassays. Basal CCK and PP plasma levels were not different between patients with CP and controls, and were not correlated in either group. However, a direct linear correlation between integrated postprandial release of CCK and PPwas found in healthy subjects (r=0.74, P<0.005). This postprandial coupling was not evident in patients with CP (r=0.16; n.s.). Peak fluorescein serum concentration in patients with CP and steatorrhea (SCP) (n=6) was <2.5 mu g/ml, and CCK and PP responses to the meal were significantly impaired (CCK response = 61 +/- 14 pmol/1/120 min in SCP vs. 110 +/- 14 in controls, P<0.05; PP response = 3920 +/- 1773 pg/ml/120 min in SCP vs. 13418 +/- 3299 in controls, P<0.05). In patients with mild/moderate exocrine insufficiency, CCK and PP responses varied greatly and were not different from controls. Response of PP, but not CCK, was significantly correlated with the PLT

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Documento generato il 29/11/20 alle ore 03:33:58