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Titolo:
BROMOCRYPTINE REVERSES THE INHIBITORY EFFECT OF MACROPHAGES ON HUMAN SPERM MOTILITY
Autore:
SCOMMEGNA A; YE SH; PRINS GS;
Indirizzi:
UNIV ILLINOIS,DEPT OBSTET & GYNECOL,820 S WOOD ST M-C 808 CHICAGO IL 60612 MICHAEL REESE HOSP & MED CTR,DEPT OBSTET & GYNECOL CHICAGO IL 00000
Titolo Testata:
Fertility and sterility
fascicolo: 2, volume: 61, anno: 1994,
pagine: 331 - 335
SICI:
0015-0282(1994)61:2<331:BRTIEO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERITONEAL-FLUID; LYMPHOCYTE-T; PROLACTIN; ENDOMETRIOSIS; RECEPTORS; INFERTILITY; LYMPHOKINES; ACTIVATION; MONOKINES; HAMSTER;
Keywords:
MACROPHAGES; ENDOMETRIOSIS; PROLACTIN; SPERM MOTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
A. Scommegna et al., "BROMOCRYPTINE REVERSES THE INHIBITORY EFFECT OF MACROPHAGES ON HUMAN SPERM MOTILITY", Fertility and sterility, 61(2), 1994, pp. 331-335

Abstract

Objective: To determine the effects of PRL suppression on the activation of murine peritoneal macrophages and their subsequent effects on human sperm motility. Design: Laboratory study. Interventions: Mice were treated with subcutaneous implants of 2.5 mg bromocryptine pellets 7days before bacillus of calmette and guerin (BCG), a strain of Mycobacterium bovis, injection for activation of macrophages. Bromocryptine treatment, which significantly suppressed circulating PRL levels, continued through the day of peritoneal macrophage collection. Macrophageswere subsequently cultured for 4 days and culture supernatant was collected. Main Outcome Measures: Human sperm were incubated for 4 hours in the presence of culture medium or culture supernatant from control and treated mice. Motion analysis was performed at 0, 2, and 4 hours. Results: A significant decrease in human sperm motility was observed in the presence of culture supernatant from activated murine peritonealmacrophages. After 4 hours of incubation, sperm motility decreased from 69% +/- 3% in the nonactivated macrophage control group to 37% +/- 6% in the BCG- activated macrophage group. The suppressive effect of soluble products of activated macrophages on human sperm motility was reversed when mice were rendered hypoprolactinemic with bromocryptine. Motility after 4 hours was 56% +/- 3% in the BCG-bromocryptine group. Simultaneous administration of bromocryptine and PRL (100 ng per mousedaily) restored the inhibitory effect of soluble products of activated macrophages on sperm motility (36% +/- 5% motile). Conclusions: PRL may modulate the deleterious effects of activated macrophages on humansperm motility, thereby suggesting novel and useful methods for the modification of the immune response in early reproduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:24:23