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Titolo:
FREQUENCY-DEPENDENT EFFECTS ON CA-I TRANSIENTS AND CELL SHORTENING INMYOCYTES THAT SURVIVE IN THE INFARCTED HEART
Autore:
LICATA A; AGGARWAL R; ROBINSON RB; BOYDEN P;
Indirizzi:
COLUMBIA UNIV,DEPT PHARMACOL NEW YORK NY 10027 COLUMBIA UNIV,DEPT PHARMACOL NEW YORK NY 10027
Titolo Testata:
Cardiovascular Research
fascicolo: 2, volume: 33, anno: 1997,
pagine: 341 - 350
SICI:
0008-6363(1997)33:2<341:FEOCTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRICULAR MYOCYTES; EPICARDIAL BORDER ZONE; CYTOSOLIC FREE CALCIUM; INTRACELLULAR CALCIUM; MYOCARDIAL-INFARCTION; METABOLIC INHIBITION; CONTRACTILE FAILURE; CANINE HEART; MECHANISM; ISCHEMIA;
Keywords:
CALCIUM, INTRACELLULAR CONCENTRATION; FURA-2; MYOCARDIAL INFARCTION; EPICARDIAL BORDER ZONE; DOG, VENTRICLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A. Licata et al., "FREQUENCY-DEPENDENT EFFECTS ON CA-I TRANSIENTS AND CELL SHORTENING INMYOCYTES THAT SURVIVE IN THE INFARCTED HEART", Cardiovascular Research, 33(2), 1997, pp. 341-350

Abstract

Myocytes that survive in the epicardial border zone of the healing canine infarcted heart provide the substrate for inducible reentrant ventricular arrhythmias. These myocytes have been shown to have altered Ca2+ currents which could impact on Ca2+ homeostasis in these cells. Objective and Methods: To directly measure and compare intracellular Ca2 transients and cell shortening in myocytes dispersed from control noninfarcted hearts with those from epicardial border zone of 5 day infarcted canine hearts using the Ca2+ sensitive indicator fura-2/AM. Studies were designed to determine and compare the effects of rate and premature stimulation on intracellular Ca2+ in the two cell types. Results: Epicardial cells from noninfarcted hearts (1) exhibited an increasein amplitude of the fura-2 ratio with decreasing pacing cycle length (CL), while cells from the infarcted heart showed the opposite effect;(2) showed more marked acceleration of relaxation of the Cai transient with decreasing CL than myocytes from the infarcted heart; (3) exhibited little or no post rest potentiation in contrast to cells from theinfarcted heart; and (4) showed a more rapid recovery during restitution protocols than cells from the infarcted heart. Cell shortening differences were also observed between cell populations in that most cells from the infarcted zone did not show any degree of cell shortening despite the reasonable intracellular Ca2+ transient. Conclusions: The handling of intracellular Ca2+ in myocytes that have survived in the epicardial border zone is very different from that of normal epicardial myocytes suggesting that there may exist marked heterogeneity in intracellular Ca2+ handling in cells in the in situ healing infarcted heart. Electrophysiologic implications of these findings are discussed.

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Documento generato il 25/11/20 alle ore 07:37:57